Na-doped β-tricalcium phosphate: physico-chemical and in vitro biological properties

  • Laëtitia Obadia
  • Marion Julien
  • Sophie Quillard
  • Thierry Rouillon
  • Paul Pilet
  • Jérôme Guicheux
  • Bruno Bujoli
  • Jean-Michel BoulerEmail author


Synthetic calcium phosphate ceramics as β-tricalcium phosphate (Ca3(PO4)2; β-TCP) are currently successfully used in human bone surgery. The aim of this work was to evaluate the influence of the presence of sodium ion in β-TCP on its mechanical and biological properties. Five Na-doped-β-TCP [Ca10.5−x/2Na x (PO4)7, 0 ≤ x ≤ 1] microporous pellets were prepared via solid phase synthesis, and their physico-chemical data (lattice compacity, density, porosity, compressive strength, infrared spectra) denote an increase of the mechanical properties and a decrease of the solubility when the sodium content is raised. On the other hand, the in vitro study of MC3T3-E1 cell activity (morphology, MTS assay and ALP activity) shows that the incorporation of sodium does not modify the bioactivity of the β-TCP. These results strongly suggest that Na-doped-β-TCP appear to be good candidates for their use as bone substitutes.


Compressive Strength Bone Substitute Transwell Insert Calcium Phosphate Ceramic Phosphate Buffer Salt 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by CNRS “Programme Matériaux Nouveaux, Nouvelles Fonctionnalités”, Région Pays de Loire “Programme Biomatériaux S3” and Fondation Avenir pour la Recherche Médicale appliquée, étude ET2-321. Marion Julien received a fellowship from INSERM and region des Pays de la Loire.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Laëtitia Obadia
    • 1
  • Marion Julien
    • 1
  • Sophie Quillard
    • 1
  • Thierry Rouillon
    • 1
  • Paul Pilet
    • 1
  • Jérôme Guicheux
    • 1
  • Bruno Bujoli
    • 2
  • Jean-Michel Bouler
    • 1
    Email author
  1. 1.INSERM, UMR 791, LIOAD, Faculté de Chirurgie DentaireUniversité de NantesNantes Cedex 1France
  2. 2.CNRS, UMR 6230, CEISAM, UFR Sciences et TechniquesUniversité de NantesNantes Cedex 3France

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