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Magnetically mediated release of ciprofloxacin from polyvinyl alcohol based superparamagnetic nanocomposites

  • A. K. Bajpai
  • Rashmi Gupta
Article

Abstract

Polymer nanocomposites exhibiting superparamagnetic behavior have been recognized as a promising tool to achieve targeted drug delivery using external magnetic field for treating complex diseases like cancers and tumors. The present investigation attempts to design a superparamagnetic nanocomposite which could desirably deliver ciprofloxacin drug by application of varying magnetic field. In order to achieve the proposed objectives, a polymer matrix of polyvinyl alcohol-g-polymethyl methacrylate was prepared by free radical polymerization and iron oxide particles were impregnated by in situ precipitation method. The prepared nanocomposites were characterized by techniques like FTIR, electron microscopy (SEM and TEM) and XRD and magnetization studies were performed to ensure superparamagnetic behavior. The antibiotic drug ciprofloxacin was loaded onto the magnetic nanocomposites and the influence of various factors such as percent loading, chemical composition of the nanocomposite, applied magnetic field, pH of the release medium were investigated on the release profiles of the drug. The chemical integrity of the drug and its antibacterial potential were also studied. The dynamics of the release process was also examined mechanistically.

Keywords

Magnetite Iron Oxide PMMA Iron Oxide Nanoparticles Iron Oxide Particle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Ciofani G, Riggio C, Raffa VA, Menciassi A, Cuschieri A. A bi-modal approach against cancer: magnetic alginate nanoparticles for combined chemotherapy and hyperthermia. Med Hypotheses. 2009;73:80–2.CrossRefGoogle Scholar
  2. 2.
    Mahmoudi M, Simchi A, Milani AS, Stroeve P. Cell toxicity of superparamagnetic iron oxide nanoparticles. J Colloid Interface Sci. 2009;336:510–8.CrossRefGoogle Scholar
  3. 3.
    Hu SH, Liu TY, Tsai CH, Chen SY. Preparation and characterization of magnetic ferroscaffolds for tissue engineering. J Magn Magn Mater. 2007;310:2871–3.CrossRefGoogle Scholar
  4. 4.
    Jain KK. Targeted Drug Delivery for Cancer. Tech Cancer Res Treat. 2005;4(4):311–3.Google Scholar
  5. 5.
    Lubbe AS, Alexiou C, Bergemann C. Clinical Applications of Magnetic Drug Targeting. J Surg Res. 2001;95:200–6.CrossRefGoogle Scholar
  6. 6.
    Jain TK, Richey J, Strand M, Leslie-Pelecky DL, Flask CA, Labhasetwar V. Magnetic nanoparticles with dual functional properties: drug delivery and magnetic resonance imaging. Biomaterials. 2008;29:4012–21.CrossRefGoogle Scholar
  7. 7.
    Ge Y, Zhang Y, guang Xia J, Ma M, He S, Nie F, Gu N. Effect of surface charge and agglomerate degree of magnetic iron oxide nanoparticles on KB cellular uptake in vitro. Colloids Surf B. 2009;73:294–301.CrossRefGoogle Scholar
  8. 8.
    Maity D, Agarwal DC. Synthesis of iron oxide nanoparticles under oxidizing environment and their stabilization in aqueous and non-aqueous media. J Magn Magn Mater. 2007;308:46–55.CrossRefGoogle Scholar
  9. 9.
    Bajpai AK, Bajpai J, Soni SN. Preparation and characterization of electrically conductive composites of poly (vinyl alcohol)-g-poly (acrylic acid) hydrogels impregnated with polyaniline (PANI). eXPRESS Polym Lett. 2008;2(1):26–39.CrossRefGoogle Scholar
  10. 10.
    Singh MK, Shokuhfar T, de Almeida Gracio JJ, Mendes de Sousa AC, Da Fonte Fereira JM, Garmestani H, Ahzi S. Hydroxyapatite modified with carbon nanotube-reinforced Poly(methyl methacrylate): a novel nanocomposite material for biomedical applications. Adv Funct Mater. 2008;9999:1–7.Google Scholar
  11. 11.
    Zhao H, Le Y, Liu H, Hu T, Shen Z, Yun J, Chen JF. Preparation of microsized spherical aggregates of ultrafine ciprofloxacin particles for dry powder inhalation (DPI). Powder Technol. 2009;194:81–6.CrossRefGoogle Scholar
  12. 12.
    Mockovciakova A, Orolinova Z, Matik M, Hudec P, Kmecova E. Iron oxide contribution to the modification of natural zeolite. Acta montanistica Slovaca. 2006;11:353–7.Google Scholar
  13. 13.
    Bajpai AK, Kankane S. Preparation and characterization of macroporous poly (2-hydroxyethyl methacrylate)-based biomaterials: Water sorption property and in vitro blood compatibility. J Appl Polym Sci. 2007;104:1559–71.CrossRefGoogle Scholar
  14. 14.
    Bajpai AK, Singh R. Study of biomineralization of poly (vinyl alcohol)-based scaffolds using an alternate soaking approach. Polym Int. 2007;56:557–68.CrossRefGoogle Scholar
  15. 15.
    Tang JG, Hu K, Liu HY, Gao D, Wu RJ. Synthesis of 10 nanometric copper clusters in a polymer matrix by a solution-reduction synthesis (SRS). J Appl Polym Sci. 2000;76:1857–64.CrossRefGoogle Scholar
  16. 16.
    McNeild ME, Graham NB. Properties controlling the diffusion and release of water-soluble solutes from poly(ethylene oxide) hydrogels. 4. Extended constant rate release from partly-coated spheres. J Biomater Sci Polym Ed. 1996;7(11):953–63.CrossRefGoogle Scholar
  17. 17.
    Bauer AW, Kirby WMM, Sherris JC, Truck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966;45:493–6.Google Scholar
  18. 18.
    Zhong ZY, Prozorov T, Felner I, Gedanken A. Sonochemical synthesis and characterization of iron oxide coated on submicrosphrical alumina: A direct observation of interaction between iron oxide and alumina. J Phys Chem B. 1999;103:947–56.CrossRefGoogle Scholar
  19. 19.
    Kryszewski M, Jeszka JK. Nanostuructured conducting polymer composites-superparamagnetic particles in conducting polymers. Synth Mater. 1998;94:99–104.CrossRefGoogle Scholar
  20. 20.
    Schwartzman V, Cornell RM. Iron oxide in the laboratory: preparation and Characterization. 2nd ed. New York: Wiley; 2000.Google Scholar
  21. 21.
    Mandal M, Kundu S, Ghosh SK, Panigrahi S, Sahu TK, Yusuf SM, Pal T. Magnetite nanoparticles with tunable gold or silver shell. J Colloid Interface Sci. 2005;286:187–94.CrossRefGoogle Scholar
  22. 22.
    Bajpai AK, Bundela H. Designing of hydroxyapatite-gelatin based porous matrix as bone substitute: Correlation with biocompatibility aspects. eXPRESS Polym Lett. 2008;2:201–13.CrossRefGoogle Scholar
  23. 23.
    Gupta B, Kothari VK. Manufactured Fiber Technology. London: Chapman & Hall; 1997. p. 225.Google Scholar
  24. 24.
    Morales M, Jain TK, Labhasetwar V. Magnetic studies of iron oxide nanoparticles coated with oleic acid and pluronic® block copolymer. J Appl Phys. 2005;97:10Q905 (1-3).Google Scholar
  25. 25.
    Chia CH, Zakaria S, Ahamd S, Abdullah M, Jani SM. Preparation of magnetic paper from kenaf: lumen loading and in situ synthesis method. Am J Appl Sci. 2006;3:1750–4.CrossRefGoogle Scholar
  26. 26.
    Szaba D, Czako-Nagy I, Zrinyi M, Vertws A. Magnetic and mossbauer studies of magnetite loaded polyvinyl alcohol hydrogels. J Colloid Interface Sci. 2000;221:166–72.CrossRefGoogle Scholar
  27. 27.
    Rana S, Gallo A, Srivastava RS, Mishra RD. On the suitability of nanocrystalline ferrites as a magnetic carrier for drug delivery: functionalization, conjugation and drug release kinetics. Acta Biomater. 2007;3:233–42.CrossRefGoogle Scholar
  28. 28.
    Bajpai AK, Mishra A. Carboxymethyl cellulose (CMC) based semi-IPNs as carriers for controlled release of ciprofloxacin: an in vitro dynamic study. J Mater Sci: Mater Med. 2008;19:2121–30.CrossRefGoogle Scholar
  29. 29.
    Bajpai AK. Adsorption of a blood protein on to hydrophilic sponges based on poly(2-hydroxyethyl methacrylate). J Mater Sci: Mater Med. 2004;15:583–92.CrossRefGoogle Scholar
  30. 30.
    Bajpai AK, Choubey J. Investigation on magnetically controlled delivery of doxorubicin from superparamagnetic nanocarriers of gelatin crosslinked with genipin. J Mater Sci: Mater Med. 2010;21:1573–86.CrossRefGoogle Scholar
  31. 31.
    Flory PJ. Principles of Polymer Chemistry. Ithaca: Cornell University Press; 1953.Google Scholar
  32. 32.
    Djurdjevic P, Stankov MJ, Odovic J. Study of solution equilibria between iron(III) ion and ciprofloxacin in pure nitrate ionic medium and micellar medium. Polyhedron. 2000;19:1085–96.CrossRefGoogle Scholar
  33. 33.
    Wang LF, Chen WB, Chen YB, Lu SC. Effects of the preparation methods of hydroxypropyl methylcellulose/polyacrylic acid blended films on drug release. J Biomater Sci: Polym Ed. 2003;14(1):27–44.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Bose Memorial Research Laboratory, Department of ChemistryGovernment Autonomous Science CollegeJabalpurIndia

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