Calcium phosphate substitutes drug delivery systems are well known substances used in minor bone void-filling to release their therapeutic agent in situ. Few studies associating anaesthetics and analgesics have been performed to date. The aim of this work was to study the association of the analgesic, morphine, and the local anaesthetic, lidocaine, with a calcium deficient apatite matrix. Three types of biomaterials i.e. powders, granules and blocks, were prepared by isostatic compression, wet granulation and a combination of the two, evaluated and compared. The chemical structure of the associated therapeutic agent was studied and the characteristics of the drug delivery systems were appraised in terms of drug release. The integrity of the lidocaine hydrochloride structure, as determined by RMN 1H, was confirmed regardless of the formulation technique used (isostatic compression or wet granulation). However, analyses of morphine hydrochloride by RMN 1H revealed slight structural modifications. The association and formulation techniques that were used made it possible to obtain an in vitro release time varying from 1 to 4 days for lidocaine hydrochloride and from 1 to 3 days for morphine hydrochloride.
Morphine Lidocaine Drug Delivery System Release Profile Calcium Phosphate
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The authors are grateful to Pr Muriel Duflos from BioCit (UPRES EA 1155), University of Nantes, for NMR analysis; Mrs Anne-Françoise Miegeville from the Laboratoire de Thérapeutiques Cliniques et Expérimentales (EA 3826), University of Nantes, for device assistance. This work was supported by Graftys SA.
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