Journal of Materials Science: Materials in Medicine

, Volume 21, Issue 11, pp 3009–3018 | Cite as

In vitro and in vivo behavior of ketoprofen intercalated into layered double hydroxides

  • Mihaela Silion
  • Doina Hritcu
  • Irina M. Jaba
  • Bogdan Tamba
  • Dunarea Ionescu
  • Ostin C. Mungiu
  • Ionel Marcel Popa


Ketoprofen (Ket) was intercalated into layered double hydroxides (ZnAlLDH and MgAlLDH) using the ionic exchange method. The drug intercalation was confirmed by X-ray diffraction (XRD) and FTIR spectroscopy. Ket release from the inorganic matrix was studied at pH 7.4 in continuous regime with a flow rate of 0.5 and respectively 1.0 ml/min. The kinetical data were interpreted using the Ritger and Peppas model. The data prove that the release kinetics and mechanism depend on the eluent flow rate. Quantification of gastric tolerance shows that the ulcerogenic effect of the intercalated drug is lower than the one of the raw Ket. The antinociceptive effect of both formulations was studied by the hot-plate method performed on mice. The MgAlLDH_Ket formulation shows a tendency towards a stronger antinociceptive effect than its ZnAlLDH_Ket counterpart during the 210 min recorded period.



This research was financially supported by the European Social Fund—„Cristofor I. Simionescu“ Postdoctoral Fellowship Programme (ID POSDRU/89/1.5/S/55216), Sectoral Operational Programme Human Resources Development 2007–2013.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Mihaela Silion
    • 1
  • Doina Hritcu
    • 2
  • Irina M. Jaba
    • 3
  • Bogdan Tamba
    • 3
  • Dunarea Ionescu
    • 3
  • Ostin C. Mungiu
    • 3
  • Ionel Marcel Popa
    • 2
  1. 1.Petru Poni Institute of Macromolecular Chemistry IasiIasiRomania
  2. 2.Faculty of Chemical Engineering and Environmental ProtectionTechnical University Gh. AsachiIasiRomania
  3. 3.Center for the Study and Therapy of PainGr. T. Popa University of Medicine and Pharmacy IasiIasiRomania

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