Bone regeneration with glass ceramic implants and calcium phosphate cements in a rabbit cranial defect model

  • Gerlind Schneider
  • Karin Blechschmidt
  • Dirk Linde
  • Peter Litschko
  • Thomas Körbs
  • Eggert Beleites


Hydroxyapatite cement (BoneSource®) and brushite calcium phosphate cement (chronOS™ Inject) were tested for fixation of glass ceramic implants (Bioverit®) in experimentally created cranial defects in 24 adult New Zealand White rabbits. Aim of the in vivo study was to assess and compare the biocompatibility and osseointegration of the implanted materials. Macroscopic and histological evaluations were performed 1 month, 3 months, and 6 months postoperatively. All implanted materials were well tolerated by the surrounding tissue. Both bone cements exhibited osteoconductive properties. Differences could be detected regarding to the rates of cement resorption and new bone formation. The brushite cement was resorbed faster than the hydroxyapatite cement. The chronOS™ Inject samples exhibited a higher rate of connective tissue formation and an insufficient osseointegration. BoneSource® was replaced by bone with minimal invasion of connective tissue. New bone formation occurred faster compared to the chronOS™ Inject group. Bioverit® implants fixed with BoneSource® were successfully osseointegrated.



We wish to thank Mathys Medical Ltd. and Stryker Leibinger for providing the bone cements used in this study and Mathys Medical Ltd. for partial financial support of the animal experiments. We are grateful to Dr. H. Schubert and Mrs. P. Dobermann (Institute for Animal Experiments of the School of Medicine, Friedrich Schiller University Jena) for performing the anaesthesia of the rabbits and their perioperative care. This study was founded by the German Federal Ministry of Economics and Technology.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Gerlind Schneider
    • 1
  • Karin Blechschmidt
    • 1
  • Dirk Linde
    • 1
  • Peter Litschko
    • 2
  • Thomas Körbs
    • 2
  • Eggert Beleites
    • 1
  1. 1.Department of Otorhinolaryngology, Faculty of MedicineFriedrich Schiller UniversityJenaGermany
  2. 2.3di GmbHJenaGermany

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