Optimisation of the mechanical and handling properties of an injectable calcium phosphate cement

  • R. M. O’Hara
  • N. J. Dunne
  • J. F. Orr
  • F. J. Buchanan
  • R. K. Wilcox
  • D. C. Barton


Calcium phosphate cements have the potential to be successful in minimally invasive surgical techniques, like that of vertebroplasty, due to their ability to be injected into a specific bone cavity. These bone cements set to produce a material similar to that of the natural mineral component in bone. Due to the ceramic nature of these materials they are highly brittle and it has been found that they are difficult to inject. This study was carried out to determine the factors that have the greatest effect on the mechanical and handling properties of an apatitic calcium phosphate cement with the use of a Design of Experiments (DoE) approach. The properties of the cement were predominantly influenced by the liquid:powder ratio and weight percent of di-sodium hydrogen phosphate within the liquid phase. An optimum cement composition was hypothesised and tested. The mechanical properties of the optimised cement were within the clinical range for vertebroplasty, however, the handling properties still require improvement.


Compressive Strength Calcium Phosphate Cement Setting Reaction Final Setting Time Handling Property 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors would like to acknowledge the financial support provided by Engineering and Physical Sciences Research Council (EP/E022863/1).


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • R. M. O’Hara
    • 1
  • N. J. Dunne
    • 1
  • J. F. Orr
    • 1
  • F. J. Buchanan
    • 1
  • R. K. Wilcox
    • 2
  • D. C. Barton
    • 2
  1. 1.School of Mechanical & Aerospace EngineeringQueen’s University of BelfastBelfastNorthern Ireland, UK
  2. 2.School of Mechanical EngineeringLeeds UniversityLeedsUK

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