Journal of Materials Science: Materials in Medicine

, Volume 21, Issue 2, pp 807–813

Development of novel chitin/nanosilver composite scaffolds for wound dressing applications

  • K. Madhumathi
  • P. T. Sudheesh Kumar
  • S. Abhilash
  • V. Sreeja
  • H. Tamura
  • K. Manzoor
  • S. V. Nair
  • R. Jayakumar
Article

DOI: 10.1007/s10856-009-3877-z

Cite this article as:
Madhumathi, K., Sudheesh Kumar, P.T., Abhilash, S. et al. J Mater Sci: Mater Med (2010) 21: 807. doi:10.1007/s10856-009-3877-z

Abstract

Antibiotic resistance of microorganisms is one of the major problems faced in the field of wound care and management resulting in complications like infection and delayed wound healing. Currently a lot of research is focused on developing newer antimicrobials to treat wounds infected with antibiotic resistant microorganisms. Silver has been used as an antimicrobial agent for a long time in the form of metallic silver and silver sulfadiazine ointments. Recently silver nanoparticles have come up as a potent antimicrobial agent and are finding diverse medical applications ranging from silver based dressings to silver coated medical devices. Chitin is a natural biopolymer with properties like biocompatibility and biodegradability. It is widely used as a scaffold for tissue engineering applications. In this work, we developed and characterized novel chitin/nanosilver composite scaffolds for wound healing applications. The antibacterial, blood clotting and cytotoxicity of the prepared composite scaffolds were also studied. These chitin/nanosilver composite scaffolds were found to be bactericidal against S. aureus and E. coli and good blood clotting ability. These results suggested that these chitin/nanosilver composite scaffolds could be used for wound healing applications.

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • K. Madhumathi
    • 1
  • P. T. Sudheesh Kumar
    • 1
  • S. Abhilash
    • 1
  • V. Sreeja
    • 1
  • H. Tamura
    • 2
  • K. Manzoor
    • 1
  • S. V. Nair
    • 1
  • R. Jayakumar
    • 1
  1. 1.Amrita Centre for Nanosciences, Amrita Institute of Medical Sciences and Research CentreAmrita Vishwa Vidyapeetham UniversityKochiIndia
  2. 2.Faculty of Chemistry, Materials and Bioengineering and High Technology Research CentreKansai UniversityOsakaJapan

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