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Development of novel chitin/nanosilver composite scaffolds for wound dressing applications

  • K. Madhumathi
  • P. T. Sudheesh Kumar
  • S. Abhilash
  • V. Sreeja
  • H. Tamura
  • K. Manzoor
  • S. V. Nair
  • R. JayakumarEmail author
Article

Abstract

Antibiotic resistance of microorganisms is one of the major problems faced in the field of wound care and management resulting in complications like infection and delayed wound healing. Currently a lot of research is focused on developing newer antimicrobials to treat wounds infected with antibiotic resistant microorganisms. Silver has been used as an antimicrobial agent for a long time in the form of metallic silver and silver sulfadiazine ointments. Recently silver nanoparticles have come up as a potent antimicrobial agent and are finding diverse medical applications ranging from silver based dressings to silver coated medical devices. Chitin is a natural biopolymer with properties like biocompatibility and biodegradability. It is widely used as a scaffold for tissue engineering applications. In this work, we developed and characterized novel chitin/nanosilver composite scaffolds for wound healing applications. The antibacterial, blood clotting and cytotoxicity of the prepared composite scaffolds were also studied. These chitin/nanosilver composite scaffolds were found to be bactericidal against S. aureus and E. coli and good blood clotting ability. These results suggested that these chitin/nanosilver composite scaffolds could be used for wound healing applications.

Keywords

Chitosan Chitin Silver Nanoparticles Silver Nitrate Composite Scaffold 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

One of the authors R. Jayakumar is grateful to SERC Division, Department of Science and Technology (DST), India, for providing the fund under the scheme of “Fast Track Scheme for Young Investigators” (Ref. No. SR/FT/CS-005/2008). Dr. S. V. Nair also grateful to DST, India, which partially supported this work, under a center grant of the Nanoscience and Nanotechnology Initiative program monitored by Dr. C. N. R. Rao. The authors are also thankful to Mr. Sajin. P. Ravi for his help in SEM studies.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • K. Madhumathi
    • 1
  • P. T. Sudheesh Kumar
    • 1
  • S. Abhilash
    • 1
  • V. Sreeja
    • 1
  • H. Tamura
    • 2
  • K. Manzoor
    • 1
  • S. V. Nair
    • 1
  • R. Jayakumar
    • 1
    Email author
  1. 1.Amrita Centre for Nanosciences, Amrita Institute of Medical Sciences and Research CentreAmrita Vishwa Vidyapeetham UniversityKochiIndia
  2. 2.Faculty of Chemistry, Materials and Bioengineering and High Technology Research CentreKansai UniversityOsakaJapan

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