Journal of Materials Science: Materials in Medicine

, Volume 20, Issue 9, pp 1945–1953

Immobilization of lactobionic acid on the surface of cadmium sulfide nanoparticles and their interaction with hepatocytes

  • K. M. Kamruzzaman Selim
  • Zhi-Cai Xing
  • Haiqing Guo
  • Inn-Kyu Kang
Article

DOI: 10.1007/s10856-009-3741-1

Cite this article as:
Kamruzzaman Selim, K.M., Xing, ZC., Guo, H. et al. J Mater Sci: Mater Med (2009) 20: 1945. doi:10.1007/s10856-009-3741-1

Abstract

In the current study, β-galactose-carrying lactobionic acid (LA) was conjugated on the surface of mercaptoacetic acid-coated cadmium sulfide nanoparticles (CSNPs) to ensure specific recognition of liver cells (hepatocytes) and to enhance biocompatibility. Maltotrionic acid-coated CSNPs (MCSNPs) were also prepared for use as a control. The results showed that LA-immobilized CSNPs (LCSNPs) were selectively and rapidly internalized into hepatocytes and emitted more intense fluorescence images as well as demonstrated increased biocompatible behavior in vitro than those of CSNPs and MCSNPs. Furthermore, the uptake amount of LCSNPs into hepatocytes was higher than that of CSNPs and MCSNPs. All these results indicate that LCSNPs may find ever-growing applications in biological labels and detection or contrast agents in life science and medical diagnostics.

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • K. M. Kamruzzaman Selim
    • 1
  • Zhi-Cai Xing
    • 1
  • Haiqing Guo
    • 2
  • Inn-Kyu Kang
    • 1
  1. 1.Department of Polymer ScienceKyungpook National UniversityDaeguSouth Korea
  2. 2.School of Molecular Engineering and ChemistryPeking UniversityBeijingChina

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