Preparation and properties of a novel drug delivery system with both magnetic and biomolecular targeting

  • Yong Yang
  • Ji-Sen Jiang
  • Bing Du
  • Zhi-Feng Gan
  • Min Qian
  • Ping Zhang
Article

DOI: 10.1007/s10856-008-3577-0

Cite this article as:
Yang, Y., Jiang, JS., Du, B. et al. J Mater Sci: Mater Med (2009) 20: 301. doi:10.1007/s10856-008-3577-0

Abstract

By loading doxorubicin (DOX) on 5-carboxyl-fluorescein (FAM) labeled AGKGTPSLETTP peptide (A54) coupled starch-coated iron oxide nanoparticles (SIONs), we prepared a novel aqueous drug delivery system with both magnetic and biomolecular targeting, which was specific to human hepatocellular carcinoma cell line BEL-7402. The saturated extent of adsorption reached 2.0 mg DOX/mg A54-SIONs at 28°C, which provided a rather high dose of DOX loading for application. Tests in vitro demonstrated the specificity of DOX-loaded A54-SIONs to BEL-7402 cells. The microscopy images proved that DOX-loaded A54-SIONs were successfully targeted to tumor tissue of nude mice with an external magnetic field in vivo. MTT assay showed higher cytostatic effect of DOX-loaded A54-SIONs to hepatocellular carcinoma cells BEL-7402 than that of DOX-loaded SIONs.

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Yong Yang
    • 1
  • Ji-Sen Jiang
    • 1
  • Bing Du
    • 2
  • Zhi-Feng Gan
    • 1
  • Min Qian
    • 2
  • Ping Zhang
    • 2
  1. 1.Department of Physics, Center of Functional Nanomaterials and DevicesEast China Normal UniversityShanghaiPeople’s Republic of China
  2. 2.School of Life ScienceEast China Normal UniversityShanghaiPeople’s Republic of China

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