Injectable acrylic bone cements for vertebroplasty based on a radiopaque hydroxyapatite. Formulation and rheological behaviour
- 252 Downloads
The utilization of injectable acrylic bone cement is crucial to the outcome of vertebroplasty and kyphoplasty. However, only a few cements that are in clinical use today are formulated specifically for use in these procedures and even these formulations are not regarded as “ideal” injectable bone cements. The aim of this work is to prepare bioactive bone cements by adding strontium hydroxyapatite (SrHA) to a cement formulation based on polymethylmethacrylate. Thus, the cement combines the immediate mechanical support given by the setting of the acrylic matrix with optimum radiopacity and bioactivity due to the incorporation of the SrHA. Formulations of bioactive cement were prepared with 10 and 20 wt% of SrHA as synthesised and after a surface treatment with the monomer. Cements loaded with treated particles showed an enhancement of their handling properties, and hence, an improvement on their rheological behaviour, injectabilities and compressive parameters. Further experiments were also carried out to determine their bioactivity and biocompatibility and results appear in other publication.
KeywordsPMMA Simulated Body Fluid Bone Cement Acrylic Bone Cement Cement Formulation
This research was supported, by MCYT (MAT2007-63355) and a Predoctoral Fellowship from the University of the Basque Country (9/UPV 00203.215-13540/2001).
- 1.N. Amoretti, E. Hovorka, P. Marcy, C. Lamasse, P. Brunner, C. Roux, P. Chevallier, P. Boileau, J. Bruneton, Burst fracture of the spine involving vertebrae presenting no other lesions: The role of vertebroplasty. Clin. Imaging 29, 379–382 (2005). doi: 10.1016/j.clinimag.2005.07.006 PubMedCrossRefGoogle Scholar
- 9.S. Shinzato, M. Koyashi, W.F. Mousa, M. Kamimura, M. Neo, Y. Kitamura, T. Kokubo, T. Nakamura, Bioactive polymethyl methacrylate-based bone cement: comparison of glass beads, apatite- and wollastonite-containing glass-ceramic and hydroxyapatite fillers on mechanical and biological properties. J Biomed. Mater. Res. 51, 258–272 (2000). doi :10.1002/(SICI)1097-4636(200008)51:2<258::AID-JBM15>3.0.CO;2-SGoogle Scholar
- 15.S. Belkoff, H. Deramond, J. Mathis, L. Jasper, Vertebroplasty: the biomechanical effect of cement volume. 46th Annual Meeting, Orthopaedic Research Society, Orlando, Florida, 2000, p. 0356Google Scholar
- 16.T. Clineff, E. Erbe, G. Gualtieri, B. Carroll, Quantitative evaluation of bone apposition to cortoss at 1 year. 46th Annual Meeting, Orthopaedic Research Society, Orlando, Florida, 2000, p. 0999Google Scholar
- 17.Y.W. Li, J.C.Y. Leong, W.W. Lu, K.D.K. Luk, K.M.C. Cheung, K.Y. Chiu, S.P. Chow, A novel injectable bioactive bone cement for spinal surgery: A developmental and preclinical study. J. Biomed. Mater. Res. A 52, 164–170 (2000). doi :10.1002/1097-4636(200010)52:1<164::AID-JBM21>3.0.CO;2-RGoogle Scholar
- 21.ISO 5833:2002 (E). Implants for surgery—acrylic resin cementsGoogle Scholar
- 22.B. Pascual, B. Vázquez, M. Gurruchaga, I. Goñi, P. Ginebra, J. Gil, J.A. Planell, B. Levenfeld, J. San Román, New aspects of the effect of size and size distribution on the setting parameters and mechanical properties of acrylic bone cements. Biomaterials 17, 509–516 (1996). doi: 10.1016/0142-9612(96)82725-6 PubMedCrossRefGoogle Scholar
- 26.L. Hernández, P. Parra, B. Vázquez, A. López-Bravo, F. Collía, I. Goñi, M. Gurruchaga, J. San Román, Injectable acrylic bone cements for vertebroplasty based on a radiopaque hydroxyapatite. Bioactivity and biocompatibility. J. Biomed. Mat. Res.-B (2008). doi: 10.1002/jbm.b.31156