Formation of composites comprised of calcium deficient HAp and cross-linked gelatin

  • Ahmed H. Touny
  • Cato Laurencin
  • Lakshmi Nair
  • Harry Allcock
  • Paul W. Brown
Article

Abstract

Cross-linked gelatin/calcium deficient hydroxyapatite (CDHAp) composites were prepared at or near physiologic temperature. α-tricalcium phosphate (α-TCP) or a mixture of tetracalcium phosphate and dicalcium phosphate were used as CDHAp precursors. Glutaraldehyde was used to cross-link the gelatin fibers. CDHAp formation reached completion in the presence of cross-linked gelatin fibers. Effects of cross-linking concentrations, proportions of gelatin fiber, molecular weight of gelatin and the temperature of the hydration reaction on the formation of CDHAp were studied. Cross-linked gelatin acts as a nucleating agent for CDHAp formation. The pH variations during CDHAp formation are lower at the onset of the reactions in the presence of cross-linked gelatin fibers. Although cross-linked gelatin fibers enhance CDHAp formation their composites have low mechanical strengths. Swelling of gelatin appears to be a major factor that limits the strengths of the CDHAp/cross-linked gelatin composites.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Ahmed H. Touny
    • 1
  • Cato Laurencin
    • 2
  • Lakshmi Nair
    • 2
  • Harry Allcock
    • 3
  • Paul W. Brown
    • 1
  1. 1.Department of Materials Science and EngineeringPenn State UniversityUniversity ParkUSA
  2. 2.Department of Orthopedic SurgeryUniversity of VirginiaCharlottesvilleUSA
  3. 3.Department of ChemistryPenn State UniversityUniversity ParkUSA

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