Journal of Materials Science: Materials in Medicine

, Volume 19, Issue 9, pp 3049–3056

Biodistribution of titanium dioxide from biologic compartments

  • Daniel G. Olmedo
  • Deborah R. Tasat
  • María Beatriz Guglielmotti
  • Rómulo Luis Cabrini
Article

DOI: 10.1007/s10856-008-3438-x

Cite this article as:
Olmedo, D.G., Tasat, D.R., Guglielmotti, M.B. et al. J Mater Sci: Mater Med (2008) 19: 3049. doi:10.1007/s10856-008-3438-x

Abstract

The layer of titanium dioxide (TiO2) of the implant is chronically exposed to the internal electrolyte milieu in the peri-implant biological compartment. Corrosion results from electrochemical attack and ensuing gradual degradation of the metallic materials and is thus of biological interest when these biomaterials are employed in clinical implantology. Herein we evaluated and compared the chronic effect and the biodistribution of TiO2 administered subcutaneously or intraperitoneally. We propose that the compartmentalization of titanium in the area of subcutaneous injection would reproduce the biological compartment of the implant and its microenvironment from which metal ions could be released and migrate systemically. Potential TiO2 deposits were identified and characterized in skin, liver and lung by histological and EDX analyses. After both treatments, the skin, liver, and lungs exhibited histological evidence of TiO2 deposits. In order to characterize in situ macrophage-like cells, tissue sections were immunohistochemically stained for CD68. Tissue specimens from all organs assayed showed positive staining for anti-macrophage monoclonal antibody CD68 (PGM1). Despite the compartmentalization of titanium within nodular areas in rats treated subcutaneously, systemic migration occurred. We concluded that systemic migration of TiO2 occurred regardless of the administration route.

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Daniel G. Olmedo
    • 1
    • 2
    • 3
  • Deborah R. Tasat
    • 4
  • María Beatriz Guglielmotti
    • 1
    • 2
  • Rómulo Luis Cabrini
    • 1
    • 5
  1. 1.Department of Oral Pathology, School of DentistryUniversity of Buenos AiresBuenos AiresArgentina
  2. 2.National Research Council (CONICET)Buenos AiresArgentina
  3. 3.Cátedra de Anatomía Patológica, Facultad de OdontologíaUniversidad de Buenos AiresBuenos AiresArgentina
  4. 4.School of Science and TechnologyUniversity of General San MartinBuenos AiresArgentina
  5. 5.Department of RadiobiologyNational Atomic Energy CommissionBuenos AiresArgentina

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