Biocompatibility evaluation of N,O-hexanoyl chitosan as a biodegradable hydrophobic polycation for controlled drug release

  • Chaonan Xu
  • Hui Pan
  • Hongliang Jiang
  • Guping Tang
  • Weiliam Chen
Article
First Online:
Received:
Accepted:

Abstract

N,O-hexanoyl chitosan (HC) displayed unique properties of excellent processibility, solubility in common organic solvents and cationic characteristics, thereby might find versatile applicaions for biomedical engineering. In this study, the biocompatibility of HC was evaluated. The effect of HC on dermal fibroblast attachment, proliferation and viability was examined in vitro, in comparison with poly(lactide-co-glycolide) (PLGA) and chitosan. The in vivo tissue response to HC was compared with PLGA implanted subcutaneously; the weight loss of the implant materials was also measured duing the degradation process. It was found that HC had no deleterious effect on the viability of dermal fibroblast. In vivo, HC displayed a favorable tissue response profile compared with PLGA, with significantly less inflammation and fibrosis. The erosion rate of HC could be modulated by changing the degree of substitution of hexanoyl groups in HC.

Keywords

Chitosan Dermal Fibroblast Chitosan Derivative Chitosan Membrane Hexanoyl 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Notes

Acknowledgments

The project was supported by National Natural Science Foundation of China under Project 20304013.

References

  1. 1.
    K.E. Uhrich, S.M. Cannizzaro, R.S. Langer, K.M. Shakesheff, Chem. Rev. 99, 3181 (1999)CrossRefGoogle Scholar
  2. 2.
    A. Södergård, M. Stolt, Prog. Polym. Sci. 27, 1123 (2002)CrossRefGoogle Scholar
  3. 3.
    N. Kumar, R.S. Langer, A.J. Domb, Adv. Drug Delivery Rev. 54, 889 (2002)CrossRefGoogle Scholar
  4. 4.
    M. Leemhuis, J.A.W. Kruijtzer, C.F. Van Nostrurn, W.E. Hennink, Biomacromolecules 8, 2943 (2007)CrossRefGoogle Scholar
  5. 5.
    M. Leemhuis, C.F. Van Nostrum, J.A.W. Kruijtzer, Z.Y. Zhong, M.R. Ten Breteler, P.J. Dijkstra, J. Feijen, W.E. Hennink, Macromolecules 39, 3500 (2006)CrossRefGoogle Scholar
  6. 6.
    A.C. Albertsson, Biomacromolecules 4, 1466 (2003)CrossRefGoogle Scholar
  7. 7.
    N.A. Peppas, P. Bures, W. Leobandung, H. Ichikaw, Eur. J. Pharm. Biopharm. 50, 27 (2000)CrossRefGoogle Scholar
  8. 8.
    M.N.V. Ravi Kumar, R.A.A. Muzzarelli, C. Muzzarelli, H. Sashiwa, A.J. Domb, Chem. Rev. 104, 6017 (2004)CrossRefGoogle Scholar
  9. 9.
    K.A. Janes, P. Calvo, M.J. Alonso, Adv. Drug Delivery Rev. 47, 83 (2001)CrossRefGoogle Scholar
  10. 10.
    G. Borchard, Adv. Drug Delivery Rev. 52, 145 (2001)CrossRefGoogle Scholar
  11. 11.
    S.J.K. Francis, H.W.T. Matthew, Biomaterials 21, 2589 (2000)CrossRefGoogle Scholar
  12. 12.
    H. Ueno, T. Mori, T. Fujinaga, Adv. Drug Delivery Rev. 52, 105 (2001)CrossRefGoogle Scholar
  13. 13.
    K. Kurita, Prog. Polym. Sci. 26, 1921 (2001)CrossRefGoogle Scholar
  14. 14.
    A. Polnok, G. Borchard, J.C. Verhoef, N. Sarisuta, H.E. Junginger, Eur. J. Pharm. Biopharm. 57, 77 (2004)CrossRefGoogle Scholar
  15. 15.
    H. Sashiwa, N. Kawasaki, A. Nakayama, E. Muraki, N. Yamamoto, H. Zhu, H. Nagano, Y. Omura, H. Saimoto, Y. Shigemasa, S.I. Aiba, Biomacromolecules 3, 1120 (2002)CrossRefGoogle Scholar
  16. 16.
    M.E.I. Badawy, E.I. Rabea, T.M. Rogge, C.V. Stevens, G. Smagghe, W. Steurbaut, M. Hofte, Biomacromolecules 5, 589 (2004)CrossRefGoogle Scholar
  17. 17.
    P. Manisara, R. Ratana, S. Pitt, J. Biomater. Sci. Polym. Edn. 17, 547 (2006)CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Chaonan Xu
    • 1
  • Hui Pan
    • 2
  • Hongliang Jiang
    • 1
  • Guping Tang
    • 3
  • Weiliam Chen
    • 2
  1. 1.Department of Polymer Science and EngineeringZhejiang UniversityHangzhouP.R. China
  2. 2.Department of Biomedical EngineeringState University of New YorkStony BrookUSA
  3. 3.Department of ChemistryZhejiang UniversityHangzhouP.R. China

Personalised recommendations