Injectability evaluation of tricalcium phosphate bone cement

  • Hugo Leonardo Rocha Alves
  • Luis A. dos Santos
  • Carlos P. Bergmann
Article

Abstract

Calcium phosphate cements are biomaterials made from a mixture of calcium phosphate powder in aqueous solutions that forms a paste that reacts at the body temperature and hardens as a result of precipitation reactions. These cements are commonly used in dentistry and orthopedic bone filling surgeries, which require extremely invasive procedures. The challenge consists in formulating an injectable paste by additives incorporation. In this work, three different additives (carboxymethylcellulose, agar polymer and sodium alginate) were incorporated to tricalcium phosphate, in concentrations of 0.4, 0.8, 1.6, 3.2 and 6.4 wt.%. Injectability was evaluated through a new method developed for this purpose. Results showed that it was possible to obtain injectable compositions of α-tricalcium phosphate cement. It was verified that the injectability depends on the rheological behavior of the pastes and injection time. In this study, pastes with viscosity suitable for good homogenization and injection were obtained.

References

  1. 1.
    L. L. HENCH and J. WILSON, in “An Introduction to Bioceramics” (World Scientific, London, 1999) p. 97Google Scholar
  2. 2.
    S. E. GRUNINGER, C. SIEW, L. C. CHOW, A. O’YOUNG, N. K. TS’AO and W. E. BROWN, J. Dent. Res. 63 (1984) 200Google Scholar
  3. 3.
    F. C. M. DRIESSENS, E. FERNÁNDEZ, M. P. GINEBRA, M. G. BOLTONG and J. A. PLANELL, Anal. Quim. Int. 93 (1997) S38Google Scholar
  4. 4.
    K. D. GROOT, in “International Symposium on Bioceramics”, Vol 17 (Lignano Sabbiadoro. Itália, 1983) p. 103Google Scholar
  5. 5.
    B. D. RATNER, in “Biomaterials Science: An Introduction to Materials in Medicine” (Academic Press, USA, 1996) p. 86Google Scholar
  6. 6.
    L. LEROUX, Z. HATIM, M. FRECHE and J. L. LACOUT, Bone 25 (1999) 31CrossRefGoogle Scholar
  7. 7.
    H. MONMA, M. GOTO and T. KOHMURA, Gypsum lime 188 (1984) 11Google Scholar
  8. 8.
    L. A. DOS SANTOS, L. C. DE OLIVEIRA, E. C. S. RIGO, R. G. CARRODEGUAS, A. O. BOSCHI and A. C. F. DE ARRUDA, Bone 25 (1999) S99CrossRefGoogle Scholar
  9. 9.
    L. C. CHOW, M. MARKOVIC, S. TAKAGI and M. CHERNG, Innov. Tech. Med. 18 (1997) 17Google Scholar
  10. 10.
    E. FERNÁNDEZ, S. SARDA, M. HAMCERENCU, M. D. VLAD, M. GEL, S. VALLS, R. TORRES and J. LÓPEZ, Biomaterials 26 (2005) 2289CrossRefGoogle Scholar
  11. 11.
    O. BERMUDEZ, M. G. BOLTONG, F. C. M. DRIESSENS and J. A. PLANELL, J. Mater. Sci.: Mater. Med. 5 (1994) 160CrossRefGoogle Scholar
  12. 12.
    R. FAMERY, N. RICHARD and O. BOCH, Ceram. Int. 20 (1994) 327CrossRefGoogle Scholar
  13. 13.
    M. P. GINEBRA, E. FERNÁNDEZ, F. C. M. DRIESSENS and J. A. PLANELL, Biomaterials 11 (1998) 243Google Scholar
  14. 14.
    ASTM C 472, in “Standard Test Methods for Physical Testing of Gypsum, Gypsum Plasters and Gypsum Concrete” (1999) p. 2Google Scholar
  15. 15.
    ASTM D 2196, in “Standard Test Methods for Rheological Properties of Non-Newtonian Materials by Rotational (Brookfield) Viscosimeter” (1986) p. 2Google Scholar
  16. 16.
    A. RATIER, M. FRECHE, J. L. LACOUT and F. RODRIGUEZ, Int. J. Pharm. 274 (2004) 261CrossRefGoogle Scholar
  17. 17.
    ASTM F 451, in “Standard Specification For Acrylic Bone Cement” (1995) p. 4Google Scholar
  18. 18.
    R. W. PHILLIPS, in “Dental Materials” (Guanabara Koogan, Rio de Janeiro, 1993). p. 196Google Scholar
  19. 19.
    I. KHAIROUN, F. C. M. DRIESSENS, M. G. BOLTONG, J. A. PLANELL and R. WENZ, Biomaterials 20 (1999) 393CrossRefGoogle Scholar
  20. 20.
    L. A. SANTOS, R. G. CARRODEGLAS, S. O. ROGERO, O. Z. HIGA, A. O. BOSCHI and A. C. F. ARRUDA, Biomaterials 23 (2002) 2035CrossRefGoogle Scholar
  21. 21.
    E. M. OOMS, E. A. EGGLEZOS, J. G. C. WOLKE and J. A. JANSEN, Biomaterials 24 (2003) 749CrossRefGoogle Scholar
  22. 22.
    K. ISHIKAWA, Y. MIYAMOTO, M. KON, M. NAGAYAMA and K. ASAOKA, Biomaterials 16 (1995) 527CrossRefGoogle Scholar
  23. 23.
    S. J. REED, in “Introduction to the Principles of Ceramic Processing” (John Wiley & Sons, Inc. 1988)Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Hugo Leonardo Rocha Alves
    • 1
  • Luis A. dos Santos
    • 1
  • Carlos P. Bergmann
    • 1
  1. 1.Department of Materials Science and EngineeringFederal University of Rio Grande do SulPorto AlegreBrazil

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