Biological responses of novel high-toughness double network hydrogels in muscle and the subcutaneous tissues

  • Yoshie Tanabe
  • Kazunori YasudaEmail author
  • Chinatsu Azuma
  • Hiroko Taniguro
  • Shin Onodera
  • Akira Suzuki
  • Yong Mei Chen
  • Jian Ping Gong
  • Yoshihito Osada


The study evaluated biological reaction of four types of novel double network gels in muscle and subcutaneous tissues, using implantation tests according to the international guideline. The implantation tests demonstrated that, although poly (2-acrylamide-2-metyl-propane sulfonic acid)/poly (N,N′-dimetyl acrylamide) (PAMPS/PDMAAm) gel induced a mild inflammation at 1 week, the degree of the inflammation significantly decreased into the same degree as that of the negative control at 4 and 6 weeks. This gel has a potential to be applied as artificial cartilage. In addition, Cellulose/Gelatin gel showed the same degree of inflammation as that of the negative control at 1 week, and then, showed a gradually absorbable property at 4 and 6 weeks. This gel has a potential to be applied as an absorbable implant. The PAMPS/polyacrylamide and Cellulose/PDMAAm gels induced a significant inflammation at each week. These DN gels are difficult to be applied as clinical implants in the current situation.


Bacterial Cellulose UHMWPE MBAA Double Network Cell Culture Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This research was financially supported by the Grant-in-Aid for Creative Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Yoshie Tanabe
    • 1
  • Kazunori Yasuda
    • 1
    Email author
  • Chinatsu Azuma
    • 1
  • Hiroko Taniguro
    • 1
  • Shin Onodera
    • 1
  • Akira Suzuki
    • 2
  • Yong Mei Chen
    • 3
  • Jian Ping Gong
    • 3
  • Yoshihito Osada
    • 3
  1. 1.Department of Sports Medicine and Joint Reconstruction Surgery, Graduate School of MedicineHokkaido UniversitySapporoJapan
  2. 2.Department of Pathology, Graduate School of MedicineHokkaido UniversitySapporoJapan
  3. 3.Division of Biological Sciences, Graduate School of ScienceHokkaido UniversitySapporoJapan

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