Biological responses of novel high-toughness double network hydrogels in muscle and the subcutaneous tissues
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The study evaluated biological reaction of four types of novel double network gels in muscle and subcutaneous tissues, using implantation tests according to the international guideline. The implantation tests demonstrated that, although poly (2-acrylamide-2-metyl-propane sulfonic acid)/poly (N,N′-dimetyl acrylamide) (PAMPS/PDMAAm) gel induced a mild inflammation at 1 week, the degree of the inflammation significantly decreased into the same degree as that of the negative control at 4 and 6 weeks. This gel has a potential to be applied as artificial cartilage. In addition, Cellulose/Gelatin gel showed the same degree of inflammation as that of the negative control at 1 week, and then, showed a gradually absorbable property at 4 and 6 weeks. This gel has a potential to be applied as an absorbable implant. The PAMPS/polyacrylamide and Cellulose/PDMAAm gels induced a significant inflammation at each week. These DN gels are difficult to be applied as clinical implants in the current situation.
KeywordsBacterial Cellulose UHMWPE MBAA Double Network Cell Culture Test
This research was financially supported by the Grant-in-Aid for Creative Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan.
- 11.C. AZUMA, K. YASUDA, Y. TANABE, H. TANIGURO, F. KANAYA, A. NAYAYAMA, Y.-M. CHEN, J. P. GONG and Y. OSADA, J. Biomed. Mater. Res. A. 81 (2007) 373Google Scholar
- 12.K. DAISAKU, T. TADA, T. KUROKAWA, J. P. GONG and Y. OSADA, Adv. Mater. 17 (2005) 5335Google Scholar
- 13.C. H. BARNETT and A. F. CONNOLD, J. Bone Joint Surg. Br. 44B (1962) 662Google Scholar
- 14.T. SASADA and H. MAEZAWA, J. Jap. Soc. Lubrication Engrs. 18 (1973) 901Google Scholar
- 15.IYAKUSHIN-HATSU No.0213001 (Official document) from Ministry of Health, Labour and Welfare, Japan: Basic concept on biological evaluation of the safety for therapeutic devices (Including transcription of Document ISO 10993-6: Biological evaluation of medial devices. Part 6: Tests for local effects after implantation), 2003Google Scholar
- 16.S. HESTRIN and M. SCHRAMM, J. Biochem. 58 (1954) 345Google Scholar