Journal of Materials Science: Materials in Medicine

, Volume 17, Issue 12, pp 1357–1364 | Cite as

Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 5: Hydrolytically degradable materials

  • Martin PřádnýEmail author
  • Jiří Michálek
  • Petr Lesný
  • Aleš Hejčl
  • Jiří Vacík
  • Miroslav Šlouf
  • Eva Syková


Macroporous hydrogels based on 2-hydroxyethyl methacrylate, 2-ethoxyethyl methacrylate and N-(2-hydroxypropyl)methacrylamide, methacrylic acid and [2-(methacryloyloxy)ethyl]trimethylammonium chloride crosslinked with N,O-dimethacryloylhydroxylamine were prepared. Hydrogels were degraded in a buffer of pH 7.4. Completely water-soluble polymers were obtained over time periods ranging from 2 to 40 days. The process of degradation was followed gravimetrically and by optical and electron microscopy. In vivo biological tests with hydrogels based on copolymers of 2-ethoxyethyl methacrylate/N-(2-hydroxypropyl)methacrylamide were performed.


HEMA Methacrylic Acid HPMA Methacrylamide Trimethylammonium Chloride 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science + Business Media, LLC 2006

Authors and Affiliations

  • Martin Přádný
    • 1
    Email author
  • Jiří Michálek
    • 1
    • 2
  • Petr Lesný
    • 2
    • 3
  • Aleš Hejčl
    • 2
    • 3
  • Jiří Vacík
    • 1
    • 2
  • Miroslav Šlouf
    • 1
  • Eva Syková
    • 2
    • 3
  1. 1.Academy of Sciences of the Czech Republic, Institute of Macromolecular ChemistryPrague 6Czech Republic
  2. 2.Center for Cell Therapy and Tissue RepairCharles UniversityPrague 5Czech Republic
  3. 3.Institute of Experimental Medicine, Academy of Sciences of the Czech RepublicPrague 4Czech Republic

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