Journal of Materials Science: Materials in Medicine

, Volume 17, Issue 12, pp 1267–1274 | Cite as

Release of diclofenac sodium from polylactide-co-glycolide 80/20 rods

  • Petrus Viitanen
  • Esa Suokas
  • Pertti Törmälä
  • Nureddin Ashammakhi
Article
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Accepted:

Abstract

Due to inflammatory reactions complicating bioabsorbable devices, the aim of this study was to develop and characterize bioabsorbable implants with anti-inflammatory drug releasing properties. Polylactide-co- glycolide (PLGA) 80/20 was compounded with diclofenac sodium (DS) to produce rods. Thermal properties were analyzed using differential scanning calorimetry (DSC). Inherent viscosity (ηinh) was measured to evaluate the drug effect on the extrude polymer. Drug release measurements were performed using UV-spectrophotometer. Five parallel samples from each type of rods were examined, first at 6 hour intervals, then on daily basis, and later twice a week. DS was released in 110 days from thinner rods and in 150 days from thicker rods. Drug release comprised a starting peak, slow release phase, then a high release phase, and a burst release phase. DSC analysis showed that DS containing rods had crystallinity in their structure. In conclusions, it is feasible to combine PLGA 80/20 and DS by using melt extrusion. Released DS concentrations reached local therapeutic levels, but the release profile was complex and therapeutic levels were not reached all the time.

Keywords

Differential Scanning Calorimetry Drug Release UHMWPE Drug Content Inherent Viscosity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science + Business Media, LLC 2006

Authors and Affiliations

  • Petrus Viitanen
    • 1
  • Esa Suokas
    • 2
  • Pertti Törmälä
    • 1
  • Nureddin Ashammakhi
    • 1
  1. 1.Institute of BiomaterialsTampere University of TechnologyTampereFinland
  2. 2.Linvatec Biomaterials Ltd.TampereFinland

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