Bone tissue reaction to Ti–48Al–2Cr–2Nb (at.%) in a rodent model: a preliminary SEM study
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A variety of metals have been used to replace the skeletal framework of human beings. Gamma titanium aluminide (γTiAl) has been recently developed as a prospective material for turbine applications. In this preliminary study, the potential of γTiAl as a biomaterial was evaluated using an in vivo rat model. Sprague–Dawley rats were implanted with γTiAl cylinders in the femur and observed for an experimental period lasting up to 180 days. The rats were sacrificed after periods of 45, 90 and 180 days. The femurs with the γTiAl implants were extracted and examined using scanning electron microscopy (SEM). Normal bone growth processes were observed as early as 45 days after γTiAl cylinder implantation. No signs of rejection of the implant metal were observed. In fact, a layered bone growth was observed on the implant metal surface. The bone–metal interface showed signs of tissue growth from original bone to the metal surface. γTiAl appears to elicit a normal bone tissue reaction and hence, has potential as a metallic implant material.