Biocompatibility studies of human fetal osteoblast cells cultured on gamma titanium aluminide

  • Omayra Rivera-Denizard
  • Nannette Diffoot-CarloEmail author
  • Vivian Navas
  • Paul A. Sundaram


Ti-48Al-2Cr-2Nb (at. %) (γTiAl), a gamma titanium aluminide alloy originally designed for aerospace applications, appears to have excellent potential for bone repair and replacement. The biological response to γTiAl implant is expected to be similar to other titanium-based biomaterials. Human fetal osteoblast cells were cultured on the surface of γTiAl and Ti-6Al-4V disks with variable surface roughness for both SEM and immunofluorescent analysis to detect the presence of collagen type I and osteonectin, proteins of the bone extracellular matrix. Qualitative results show that cell growth and attachment on γTiAl was normal compared to that of Ti-6Al-4V, suggesting that γTiAl is not toxic to osteoblasts. The presence of collagen type I and osteonectin was observed on both γTiAl and Ti-6Al-4V. The results obtained suggest γTiAl is biocompatible with the osteoblast cells.


Titanium Alloy Collagen Type Osteoblast Cell Bone Extracellular Matrix Gamma Titanium Aluminide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by the College of Arts and Sciences, University of Puerto Rico at Mayagüez. The authors are grateful to Mr. José Almodóvar, Department of Biology, University of Puerto Rico, Mayagüez, for his help with laser confocal and scanning electron microscopy.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Omayra Rivera-Denizard
    • 1
  • Nannette Diffoot-Carlo
    • 1
    Email author
  • Vivian Navas
    • 1
  • Paul A. Sundaram
    • 2
  1. 1.Department of BiologyUniversity of Puerto RicoMayaguezUSA
  2. 2.Department of Mechanical EngineeringUniversity of Puerto RicoMayaguezUSA

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