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An in vivo study of a bone grafting material consisting of hydroxyapatite and reconstituted collagen

  • Fu-Yin Hsu
  • Shiao-Wen Tsai
  • Chen-Wen Lan
  • Yng-Jiin Wang
Article

Abstract

This study aims to evaluate the performance of our recently developed microspheres of hydroxyapatite/reconstituted collagen as a bone grafting material. The microspheres were fabricated into a circular disc and implanted in a pre-drilled hole in a rat’s calvaria. The bone tissue had regenerated and grown into the disc bone graft 4 weeks following implantation. After 16 weeks of implantation, the regenerated bone had integrated with the remaining material and made close contact with it. The disc had been completely absorbed with almost no visible bone graft left after 24 weeks of implantation. In contrast, a hydroxyapatite disc still remained intact on the 24th week after implantation. These results suggested that the hydroxyapatite/reconstituted collagen microsphere can be used as an excellent bone grafting material.

Keywords

Collagen Polymer Hydroxyapatite Bone Tissue Bone Graft 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    O. R. BEIRNE, Inter. J. Oral Maxillofac. Surg. 15 (1986) 269.Google Scholar
  2. 2.
    F. F. PARRISH, Clin. Orthop. Rel. Res. 87 (1972) 36.Google Scholar
  3. 3.
    H. J. MANKIN, M. C. GEBHARDT and W. W. TOMFORD, Orthop. Clin. North. Am. 18 (1987) 275.Google Scholar
  4. 4.
    P. D. COSTANTINO and C. D. FRIEDMAN, ibid. 27 (1994) 1037.Google Scholar
  5. 5.
    R. BELL and O. R. BEIRNE, J. Oral Maxillofac Surg. 46 (1988) 589.Google Scholar
  6. 6.
    E. HAHN, S. SONIS, G. GALLAGHER and D. ATWOOD, J. Prosthet. 60 (1988) 729.Google Scholar
  7. 7.
    H. A. MAROUF, A. A. QUAYLE and P. SLOAN, Int. J. Oral Maxillofac Implants. 5 (1990) 148.Google Scholar
  8. 8.
    H. POHUNKOVA and M. ADAM, Biomaterials 16 (1995) 67.Google Scholar
  9. 9.
    A. SUGAYA, M. MINABE, T. TAMURA and T. HORI, J. Periodontal Res. 24 (1989) 284.Google Scholar
  10. 10.
    M. NAGASE, R. CHEN, Y. ASADA and T. NAKAJIMA, J. Oral Maxillofac. Surg. 47 (1989) 40.Google Scholar
  11. 11.
    A. R. WITTKAMPF, ibid. 46 (1988) 1019.Google Scholar
  12. 12.
    F. Y. HSU, S. H. CHEUH and Y. J. WANG, Biomaterials 20 (1999) 1931.Google Scholar
  13. 13.
    F. Y. HSU, S. W. TSAI, F. F. WANG and Y. J. WANG, Art. Cells. Blood Subs. Immob. Biotech. 28 (2000) 147.Google Scholar
  14. 14.
    R. A. MILCH, D. P. RALL and J. E. TOBIE, J. Nat. Cancer. Inst. 19 (1957) 87.Google Scholar
  15. 15.
    H. M. FROST, B. A. VILLANUEVA, H. ROTH and S. STANISAVLJEVIE, J. New Drugs. 1 (1961) 206.Google Scholar
  16. 16.
    H. E. GRUBER and P. MEKIKIAN, Biotechnic Histoch. 66 (1991) 181.Google Scholar
  17. 17.
    B. FLAUTRE, G. PASQUIER, M. C. BLARY, K. ANSELME and P. HARDOUIN, J. Mater. Sci.: Mater Medic. 7 (1996) 63.Google Scholar

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Fu-Yin Hsu
    • 1
  • Shiao-Wen Tsai
    • 2
  • Chen-Wen Lan
    • 1
  • Yng-Jiin Wang
    • 1
  1. 1.Institute of Biomedical EngineeringNational Yang Ming UniversityTaipeiTaiwan, Republic of China
  2. 2.Institute of Biochemical and Biomedical EngineeringChang Gung UniversityTao-YuanTaiwan, Republic of China

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