Salivary bisphenol-A levels detected by ELISA after restoration with composite resin

  • N. Sasaki
  • K. Okuda
  • T. KatoEmail author
  • H. Kakishima
  • H. Okuma
  • K. Abe
  • H. Tachino
  • K. Tuchida
  • K. Kubono


Bisphenol-A diglycidylether methacrylate (Bis-GMA), which is synthesized from bisphenol-A (BPA), a compound with exogenous endocrine disrupter action, is widely used as a dental material. During clinical filling with sealants and composite resins, the compounds are solidified by polymerization and then used. However, it has been noted that unpolymerized monomers may become dissolved in saliva. In this study using a competitive ELISA system, we investigated the changes in the BPA concentration in saliva after restoration with composite resins. Commercial composite resins from nine companies were tested. Mixed saliva was collected from 21 subjects. Based on the dynamics of salivary BPA detected by this ELISA system, we concluded that several tens to 100 ng/ml of BPA were contained in saliva after filling teeth with composite resin but that sufficient gargling can remove it from the oral cavity. Our data suggest that sufficient gargling after treatment is important for risk management.


Polymer Methacrylate Risk Management Oral Cavity Composite Resin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • N. Sasaki
    • 1
  • K. Okuda
    • 1
  • T. Kato
    • 1
    Email author
  • H. Kakishima
    • 2
  • H. Okuma
    • 2
  • K. Abe
    • 2
  • H. Tachino
    • 3
  • K. Tuchida
    • 3
  • K. Kubono
    • 3
  1. 1.Department of MicrobiologyTokyo Dental CollegeChibaJapan
  2. 2.Eiken Chemical Co., Ltd.TochigiJapan
  3. 3.SRL, Inc.TokyoJapan

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