A novel non-enzymatic dopamine sensors based on NiO-reduced graphene oxide hybrid nanosheets

  • Hong Yan YueEmail author
  • Hong Jie Zhang
  • Shuo Huang
  • Xin Gao
  • Shan Shan Song
  • Zhao Wang
  • Wan Qiu Wang
  • En Hao Guan


Ni(OH)2 nanoflakes (NFs) and graphene oxide (GO) nanosheets were prepared by a hydrothermal process and the modified Hummer’s method, respectively. Then, Ni(OH)2 NFs were dispersed in the GO suspension with the assistance of ultrasonic. Finally, the mixed colloidal solution was uniformly sprayed onto the surface of indium tin oxide (ITO) glass and annealed to obtain the NiO-reduced GO (RGO)/ITO electrode, which subsequently used for electrochemical sensing of dopamine (DA) analyte. The NiO-RGO/ITO electrode exhibits enhanced electrochemical response in the aqueous solution of DA analyte, which shows a high sensitivity (1.04 µA µM− 1), the lower measured detection limit (1 µM). The NiO-RGO/ITO electrode also exhibits an excellent selectivity under the interference of uric acid, repeatability and stability. The prepared sensor has been successfully applied in real samples and has a great potential to be used in clinical medicine.



We acknowledge the financial support from the Ministry of Personnel of China (2015192), Postdoctoral Initial Founding of Heilongjiang Province (LBH-Q14117), Technology Foundation for Selected Overseas Chinese Scholar, Science Funds for the Young Innovative Talents of HUST (201604) and the Innovative Talent Fund of Harbin city (2016RAQXJ185).

Supplementary material

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Supplementary material 1 (DOCX 506 KB)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Hong Yan Yue
    • 1
    Email author
  • Hong Jie Zhang
    • 1
  • Shuo Huang
    • 1
    • 2
  • Xin Gao
    • 1
  • Shan Shan Song
    • 1
  • Zhao Wang
    • 1
  • Wan Qiu Wang
    • 1
  • En Hao Guan
    • 1
  1. 1.School of Materials Science and EngineeringHarbin University of Science and TechnologyHarbinPeople’s Republic of China
  2. 2.Department of NeurologyThe First Affiliated Hospital of Harbin Medical UniversityHarbinPeople’s Republic of China

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