A novel non-enzymatic dopamine sensors based on NiO-reduced graphene oxide hybrid nanosheets
- 23 Downloads
Ni(OH)2 nanoflakes (NFs) and graphene oxide (GO) nanosheets were prepared by a hydrothermal process and the modified Hummer’s method, respectively. Then, Ni(OH)2 NFs were dispersed in the GO suspension with the assistance of ultrasonic. Finally, the mixed colloidal solution was uniformly sprayed onto the surface of indium tin oxide (ITO) glass and annealed to obtain the NiO-reduced GO (RGO)/ITO electrode, which subsequently used for electrochemical sensing of dopamine (DA) analyte. The NiO-RGO/ITO electrode exhibits enhanced electrochemical response in the aqueous solution of DA analyte, which shows a high sensitivity (1.04 µA µM− 1), the lower measured detection limit (1 µM). The NiO-RGO/ITO electrode also exhibits an excellent selectivity under the interference of uric acid, repeatability and stability. The prepared sensor has been successfully applied in real samples and has a great potential to be used in clinical medicine.
We acknowledge the financial support from the Ministry of Personnel of China (2015192), Postdoctoral Initial Founding of Heilongjiang Province (LBH-Q14117), Technology Foundation for Selected Overseas Chinese Scholar, Science Funds for the Young Innovative Talents of HUST (201604) and the Innovative Talent Fund of Harbin city (2016RAQXJ185).
- 23.N. Ye, Z. Wang, S. Wang, H. Fang, D. Wang, Aqueous aggregation and stability of graphene nanoplatelets, graphene oxide, and reduced graphene oxide in simulated natural environmental conditions: complex roles of surface and solution chemistry. Environ. Sci. Pollut. R. 25, 10956–10965 (2018)CrossRefGoogle Scholar
- 24.C. Wang, Y. Sun, X. Yu, D. Ma, J. Zheng, P. Dou et al., Ag–Pt hollow nanoparticles anchored reduced graphene oxide composites for non-enzymatic glucose biosensor. J. Mater. Sci. 27, 9370–9378 (2016)Google Scholar
- 29.Y.Y. Hong, Z. Hong, S. Huang, Y.L. Xuan, G. Xin, C. Jing et al., Synthesis of ZnO nanowire arrays/3D graphene foam and application for determination of levodopa in the presence of uric acid. Biosens. Bioelectron. 89, 592–597 (2016)Google Scholar
- 31.S.S. Choo, E.S. Kang, I. Song, D. Lee, J.W. Choi, T.H. Kim, Electrochemical detection of dopamine using 3D porous graphene oxide/gold nanoparticle composites. Sensors. 861, 1–11 (2017)Google Scholar
- 33.J. Chen, P. He, H. Bai, S. He, T. Zhang, X. Zhang et al., Poly(β-cyclodextrin)/carbon quantum dots modified glassy carbon electrode: preparation, characterization and simultaneous electrochemical determination of dopamine, uric acid and tryptophan. Sensor. Actuat. B 252, 9–16 (2017)CrossRefGoogle Scholar