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Mesoporous silica nanoparticles combined with MoS2 and FITC for fluorescence imaging and photothermal therapy of cancer cells

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Abstract

The construction of effective and safe theranostics was very important to realize tumor diagnosis and treatment simultaneously. Photothermal therapy had obtained great attention due to its remarkable capability of both cancer treatment and biosecurity. Molybdenum disulfide (MoS2) nanoflakes have shown excellent photothermal conversion efficiency, which were explored to photothermal therapy. However, MoS2 nanoflakes would decrease or quench the intensity of fluorescence when the MoS2 nanoflakes directly incorporated with fluorescence dyes to construct bioimaging theranostic systems. In this work, MoS2 nanoflakes embedded into MSNs to construct photothermal nanomaterials, which realized the nanoparticle size controllable. Fluorescein isothiocyanate (FITC) conjugated with mesoporous silica nanoparticles via amide bonds for bioimaging. It was more stable than physical absorption. As expected, the as-prepared FITC–MoS2 MSNs possessed photothermal effect, fluorescence stability and photostability. FITC–MoS2 MSNs were quickly taken up by HepG2 cells. Meanwhile, the HepG2 cells could be efficiently ablated under the 808 nm near-infrared laser irradiation. These results proved that we successfully constructed multifunctional MSNs for tumor theranostics. It also provided a potentially common nanoplatform for theranostic of biomedical applications.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 21675177, 21604048) and the Science and Technology Planning Project of Guangdong Province (No. 2016B030303002) and GDAS' Project of Science and Technology Development (2020GDASYL-20200102008).

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Authors and Affiliations

  1. Phase I Clinical Trial Unit of Xiangya Boai Rehabilitation Hospital, Changsha, 410000, China

    Jie Wang, Yamin Yin, Haisha Liu, Guohua Tang, Yanxia Ma, Xin Feng, Han Mei & Jinlian Bi

  2. Bioengineering Research Laboratory, Guangdong Bioengineering Institute (Guangzhou Sugarcane Industry Research Institute), Guangdong Academy of Sciences, Guangzhou, 510316, China

    Ke Wang

  3. School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China

    Zuanguang Chen

  4. Nanchang County People’s Hospital, Nanchang, 330000, China

    Zhifeng Li

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  1. Jie Wang
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Correspondence to Ke Wang or Zuanguang Chen.

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Wang, J., Li, Z., Yin, Y. et al. Mesoporous silica nanoparticles combined with MoS2 and FITC for fluorescence imaging and photothermal therapy of cancer cells. J Mater Sci 55, 15263–15274 (2020). https://doi.org/10.1007/s10853-020-04950-7

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