Composites of thiol-grafted PEDOT with N-doped graphene or graphitic carbon nitride as an electrochemical sensor for the detection of paracetamol

  • Yinqiang Yan
  • Ruxangul JamalEmail author
  • Zongna Yu
  • Ruanye Zhang
  • Wenli Zhang
  • Yi Ge
  • Yingcheng Liu
  • Tursun AbdiryimEmail author
Materials for life sciences


A novel electrochemical sensor with thiol-grafted PEDOT/N-doped graphene (N-Gr/PEDOT-MeSH) and thiol-grafted PEDOT/graphitic carbon nitride (g-C3N4/PEDOT-MeSH) composites was fabricated for the detection of paracetamol (PAR). The formation mechanism of the obtained structure was thoroughly studied. And from the electrochemical results, the synergistic effect between the PEDOT-MeSH and g-C3N4 or N-Gr improved the electron transfer and conductivity of the modified electrodes and enhanced the sensing responses toward the electrochemical oxidation of PAR. The calibration curve of N-Gr/PEDOT-MeSH and g-C3N4/PEDOT-MeSH composites exhibited the wider linear responses for PAR, ranging from 2 to 1680 µM and 0.4 to 1280 µM, and the detection limits (S/N = 3) were 1.42 µM and 1.0 µM, respectively. Furthermore, the obtained composites exhibited the excellent reproducibility, lower detection limit and good stability. And it was capable of detecting PAR in real samples with a satisfying result.



We gratefully acknowledge the financial support from the National Natural Science Foundation of China (Nos. 21564014, 21764014).

Compliance with ethical standards

Conflict of interest

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Supplementary material

10853_2020_4351_MOESM1_ESM.docx (288 kb)
Supplementary material 1 (DOCX 285 kb)


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Authors and Affiliations

  1. 1.Key Laboratory of Petroleum and Gas Fine Chemicals, Educational Ministry of China, School of Chemistry and Chemical EngineeringXinjiang UniversityUrumqiPeople’s Republic of China

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