Journal of Materials Science

, Volume 55, Issue 1, pp 404–420 | Cite as

Electrospinning of cyclodextrins: hydroxypropyl-alpha-cyclodextrin nanofibers

  • Asli CelebiogluEmail author
  • Tamer UyarEmail author
Polymers & biopolymers


This study summarizes the polymer-free electrospinning of nanofibers from hydroxypropyl-alpha-cyclodextrin (HP-α-CyD). The viscosity and conductivity of HP-α-CyD solutions were studied, and HP-α-CyD concentrations from 160% up to 240% (w/w) were examined in order to find the optimal conditions for the electrospinning of uniform and bead-free HP-α-CyD nanofibers. We further extend our study by considering some industrially relevant scenarios for the preparation of HP-α-CyD solutions for the electrospinning process. For instance, distilled water, tap water and salty water (i.e., 1% NaCl, w/w) were used for the preparation of HP-α-CyD solutions, which significantly change the solution conductivity, and its effect on the electrospinning of HP-α-CyD was examined. It was observed that the higher solution conductivity was the dominating factor for obtaining bead-free and thinner HP-α-CyD nanofibers from less concentrated HP-α-CyD solutions. Yet, electrospinning of HP-α-CyD from salty water having higher solution conductivity yielded less uniform HP-α-CyD nanofibrous web. Moreover, the HP-α-CyD solutions were stored for certain time period (1 h, 1 day, 2 days, 4 days and 8 days) prior to electrospinning in order to study effect of storage time of the HP-α-CyD solutions. There was no significant viscosity change for HP-α-CyD solutions over time (up to 8 days), and therefore, the electrospinning of HP-α-CyD solutions resulted similar fiber morphology regardless of storage period. In all cases, the electrospinning of HP-α-CyD nanofibers yielded self-standing nanofibrous webs in the form of flexible nonwoven structure.



This work made use of the scanning electron microscope (SEM) of the Cornell Center for Materials Research Shared Facilities which are supported through the NSF MRSEC Program (DMR-1719875). Prof. Uyar acknowledges the startup funding from the College of Human Ecology at Cornell University. The partial funding for this research was also graciously provided by Nixon Family (Lea and John Nixon) thru College of Human Ecology at Cornell University.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Fiber Science and Apparel Design, College of Human EcologyCornell UniversityIthacaUSA

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