Journal of Materials Science

, Volume 54, Issue 13, pp 9729–9744 | Cite as

Bicompartmental microparticles loaded with antibacterial agents for prolonging food shelf life

  • Nidhi Gupta
  • Agni Kr. Biswal
  • Ashok Kr. Parthipan
  • Banpreet Kaur
  • Bhavna Sharma
  • Josemon Jacob
  • Sampa SahaEmail author
Materials for life sciences


The aim of this work was to fabricate disk-shaped bicompartmental microparticles loaded with antibacterial agent (benzoic acid) using electrohydrodynamic co-jetting technique for prolonging food shelf life. The particles were composed of a semi-crystalline polymer (polylactide, PLA) and an amorphous polymer (poly(lactide-co-glycolide), 50:50, PLGA) as individual compartment to encapsulate antibacterial active in either of them with a high active loading (30 wt%) and encapsulation efficiency (> 94%), and the purpose was to release the active at a desired rate depending on its location and pH of the environment. In order to utilize their controlled release characteristics (100% release over 60 days at neutral pH), the antibacterial activity of the particles was evaluated against both gram-negative and gram-positive bacteria over a period of 30 days at 37 °C and ~ 100% bacterial growth reduction was observed. Their prolonged antibacterial activity was also demonstrated on a food model (watermelon juice) over the stipulated time period.



The research leading to these results has received funding from Department of Science and Technology (DST), New Delhi, India, under Extramural research Grant: SB/S3/CE/068/2015.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

10853_2019_3577_MOESM1_ESM.docx (1 mb)
Supplementary material 1 (DOCX 1028 kb)


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Authors and Affiliations

  1. 1.Department of Materials Science and EngineeringIndian Institute of TechnologyDelhiIndia

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