Journal of Materials Science

, Volume 53, Issue 23, pp 15837–15849 | Cite as

Fast-dissolving carvacrol/cyclodextrin inclusion complex electrospun fibers with enhanced thermal stability, water solubility, and antioxidant activity

  • Zehra I. Yildiz
  • Asli Celebioglu
  • Mehmet E. Kilic
  • Engin Durgun
  • Tamer UyarEmail author
Chemical routes to materials


Carvacrol is a known antioxidant molecule and commonly used in food and cosmetics as a flavor and fragrance agent; however, carvacrol has major issues such as high volatility, low water solubility, and stability. In this study, carvacrol/cyclodextrin inclusion complex fibers (carvacrol/CD-IC fibers) were produced via electrospinning in order to enhance thermal stability, water solubility and shelf-life of carvacrol having antioxidant activity. The phase solubility and computational modeling studies showed that carvacrol can form inclusion complexes with two types of modified CDs, hydroxypropyl-β-cyclodextrin (HPβCD) and hydroxypropyl-γ-cyclodextrin (HPγCD). The carvacrol/cyclodextrin inclusion complex electrospun fibers (carvacrol/HPβCD-IC fibers and carvacrol/HPγCD-IC fibers) were obtained as free-standing fibrous webs. Although pure carvacrol is highly volatile, the electrospun carvacrol/CD-IC fibers were quite effective to preserve high amount of carvacrol due to the inclusion complexation. In addition, carvacrol/CD-IC fibers have shown higher temperature stability for carvacrol. Moreover, carvacrol/CD-IC fibers showed more effective antioxidant activity as compared to pure carvacrol. The carvacrol/CD-IC fibrous webs have shown fast-dissolving character in water due to the enhanced water solubility of carvacrol/CD-IC and their ultrafine fiber structure. In short, encapsulation of carvacrol in electrospun CD-IC fibrous webs has shown potentials for food and oral care applications due to free-standing and fast-dissolving character along with high water solubility, high temperature stability and enhanced antioxidant by carvacrol/cyclodextrin inclusion complexation.



Dr. Uyar acknowledges The Scientific and Technological Research Council of Turkey (TUBITAK), Turkey (Project #213M185) for funding this research. Z. I. Yildiz thanks to TUBITAK-BIDEB for the PhD scholarship. Dr. Durgun acknowledges the support from the Turkish Academy of Sciences—Outstanding Young Scientists Award Program (TUBA-GEBIP)—Turkey.

Supplementary material

10853_2018_2750_MOESM1_ESM.pdf (964 kb)
Supplementary material 1 (PDF 964 kb)

Supplementary material 2 (MPG 8806 kb)


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Institute of Materials Science and Nanotechnology, UNAM-National Nanotechnology Research CenterBilkent UniversityAnkaraTurkey

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