Journal of Materials Science

, Volume 53, Issue 12, pp 8887–8900 | Cite as

Biocompatible nanoclusters of O-carboxymethyl chitosan-coated Fe3O4 nanoparticles: synthesis, characterization and magnetic heating efficiency

  • P. H. Linh
  • N. V. Chien
  • D. D. Dung
  • P. H. Nam
  • D. T. Hoa
  • N. T. N. Anh
  • L. V. Hong
  • N. X. Phuc
  • P. T. Phong
Chemical routes to materials


In this work, we developed a polymer encapsulation of Fe3O4 nanoparticles as a core–shell nanocluster with different sizes to investigate the cluster structure effect on their magnetic properties and magnetic heating behavior. Well-dispersed nanoclusters of O-carboxymethyl chitosan-coated Fe3O4 nanoparticles were synthesized by microwave-assisted co-precipitation. The cluster sizes were tunable by varying the concentration of polymers used during synthesis. Nanoclusters present superparamagnetic behavior at room temperature with a reduction in saturation magnetization as a consequence of coating layer. The shift of blocking temperature to the higher value with increasing clusters size shows the stronger magnetic interaction in larger magnetic clusters. In a low alternating magnetic field with frequency of 178 Hz and amplitude of 103 Oe, nanoclusters offer a high heating efficiency. A maximum specific absorption rate of 204 W/g is observed in the sample with hydrodynamic size of 53 nm. In vitro cytotoxicity analysis performed on HeLa cells verified that nanoclusters show a good biocompatibility and can be an excellent candidate for applications in hyperthermia cancer treatment.



The Science and Technology Project of Vietnam Academy of Science and Technology (Grant No. VAST.ĐLT.05/16-17) supported this work. The authors thank Prof. Nguyen Thi Quy and Dr. Hoang Thi My Nhung, Faculty of Biology, VNU University of Science, for their support in cytotoxicity assay.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • P. H. Linh
    • 1
  • N. V. Chien
    • 1
  • D. D. Dung
    • 2
  • P. H. Nam
    • 1
  • D. T. Hoa
    • 1
  • N. T. N. Anh
    • 1
  • L. V. Hong
    • 1
  • N. X. Phuc
    • 1
    • 3
  • P. T. Phong
    • 4
    • 5
  1. 1.Institute of Materials ScienceVietnam Academy of Science and TechnologyHanoiVietnam
  2. 2.School of Engineering PhysicsHa Noi University of Science and TechnologyHanoiVietnam
  3. 3.Duy Tan UniversityDa Nang CityVietnam
  4. 4.Theoretical Physics Research Group, Advanced Institute of Materials ScienceTon Duc Thang UniversityHo Chi Minh CityVietnam
  5. 5.Faculty of Applied SciencesTon Duc Thang UniversityHo Chi Minh CityVietnam

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