Advertisement

Journal of Materials Science

, Volume 54, Issue 7, pp 5743–5756 | Cite as

TiN nanoparticles: synthesis and application as near-infrared photothermal agents for cancer therapy

  • Wenqi Jiang
  • Qingge Fu
  • Hengyong Wei
  • Aihua Yao
Materials for life sciences
  • 23 Downloads

Abstract

We have developed TiN nanoparticles (NPs) as a novel near-infrared-activated photothermal agent. The effect of nitridation temperature on the optical property and photothermal performance of the TiN NPs were investigated. The nanoparticles nitrided at 1000 °C presented a significant absorption along the whole biological spectral range (i.e., for wavelengths above 700 nm). After coated with polystyrene sulfonate (PSS) and poly(diallyldimethylammonium chloride) (PDDA), they exhibited well-defined spherical morphology with average size of ~ 50 nm. We also demonstrated their therapeutic efficacy against SW1990 pancreatic cancer cells. The results indicated that the PSS/PDDA-coated TiN NPs offered several advantages including high photothermal conversion efficiency (44.6%), high photothermal stability, broad spectral tunability, low cytotoxicity and facile synthesis process. These features make TiN NPs promising alternative for use as a photothermal agent in cancer photothermal treatment.

Notes

Acknowledgements

This work was financially supported by Research Funds for the Central Universities, National Natural Science Foundation of China (No. 50702037), Natural Science Foundation of Shanghai Municipality (No. 16ZR1400700) and Shanghai Health and Family Planning Commission Project (No. 2012y193).

References

  1. 1.
    Abadeer NS, Murphy CJ (2016) Recent progress in cancer thermal therapy using gold nanoparticles. J Phys Chem C 120:1171–1176CrossRefGoogle Scholar
  2. 2.
    Huang X, El-Sayed MA (2010) Gold nanoparticles: optical properties and implementations in cancer diagnosis and photothermal therapy. J Adv Res 1:13–28CrossRefGoogle Scholar
  3. 3.
    Jaque D, Maestro LM, Rosal B, Haro-Gonzalez P, Benayas A, Plaza JL, Rodriguez EM, Solé JG (2014) Nanoparticles for photothermal therapies. Nanoscale 6:9494–9530CrossRefGoogle Scholar
  4. 4.
    Chen HB, Zhang J, Chang KW, Men XJ, Fang XF, Zhou LB, Li DL, Gao DY, Yin SY, Zhang XJ, Yuan Z, Wu CF (2017) Highly absorbing multispectral near-infrared polymer nanoparticles from one conjugated backbone for photoacoustic imaging and photothermal therapy. Biomaterials 528:42–52CrossRefGoogle Scholar
  5. 5.
    Maestro LM, Haro-González P, Rosal B, Ramiro J, Caamaño AJ, Carrasco E, Juarranz A, Sanz-Rodriguez F, Solé JG, Jaque D (2013) Heating efficiency of multi-walled carbon nanotubes in the first and second biological windows. Nanoscale 17:7882–7889CrossRefGoogle Scholar
  6. 6.
    Smith AM, Mancini MC, Nie S (2009) Second window for in vivo imaging. Nat Nanotechnol 4:710–711CrossRefGoogle Scholar
  7. 7.
    Barchiesi D, Kessentini S (2012) Quantitative comparison of optimized nanorods, nanoshells and hollow nanospheres for photothermal therapy. Biomed Opt Express 3:590–604CrossRefGoogle Scholar
  8. 8.
    Kang S, Bhang SH, Hwang S, Yoon JK, Song J, Jang HK, Kim S, Kim BS (2015) Mesenchymal stem cells aggregate and deliver gold nanoparticles to tumors for photothermal therapy. ACS Nano 9:9678–9690CrossRefGoogle Scholar
  9. 9.
    Tang S, Chen M, Zheng N (2014) Sub-10-nm Pd nanosheets with renal clearance for efficient near-infrared photothermal cancer therapy. Small 10:3139–3144CrossRefGoogle Scholar
  10. 10.
    Zhou Z, Kong B, Yu C, Shi XY, Wang MW, Liu W, Sun YN, Zhang YJ, Yang H, Yang SP (2014) Tungsten oxide nanorods: an efficient nanoplatform for tumor CT imaging and photothermal therapy. Sci Rep 41:3653–3662Google Scholar
  11. 11.
    Cheng L, Gong H, Zhu W, Liu J, Wang X, Liu G, Liu Z (2014) PEGylated Prussian blue nanocubes as a theranostic agent for simultaneous cancer imaging and photothermal therapy. Biomaterials 35:9844–9852CrossRefGoogle Scholar
  12. 12.
    Zhou M, Li J, Liang S, Sood AK, Liang D, Li C (2015) CuS nanodots with ultrahigh efficient renal clearance for positron emission tomography imaging and image-guided photothermal therapy. ACS Nano 9:7085–7096CrossRefGoogle Scholar
  13. 13.
    Robinson JT, Tabakman SM, Liang Y, Liang Y, Wang H, Casalonque HS, Vinh D, Dai H (2011) Ultrasmall reduced graphene oxide with high near-infrared absorbance for photothermal therapy. J Am Chem Soc 133:6825–6831CrossRefGoogle Scholar
  14. 14.
    Liu X, Lloyd MC, Fedorenko IV, Bapat P, Zhukov T, Huo Q (2008) Enhanced imaging and accelerated photothermalysis of A549 human lung cancer cells by gold nanospheres. Nanomedicine 3:617–626CrossRefGoogle Scholar
  15. 15.
    Shao J, Griffin RJ, Galanzha EI, Kim JW, Koonce N, Webber J, Mustafa T, Biris AS, Nedosekin DA, Zharov VP (2013) Photothermal nanodrugs: potential of TNF-gold nanospheres for cancer theranostics. Sci Rep 3:1293–1301CrossRefGoogle Scholar
  16. 16.
    Gao YP, Li YS, Wang Y, Chen Y, Gu JL, Zhao WR, Ding J, Shi JL (2015) Controlled synthesis of multilayered gold nanoshells for enhanced photothermal therapy and SERS detection. Small 11:77–83CrossRefGoogle Scholar
  17. 17.
    Zhang ZP, Xu SH, Wang Y, Yu YN, Li FZ, Zhu H, Shen YY, Huang ST, Guo SR (2017) Near-infrared triggered co-delivery of doxorubicin and quercetin by using gold nanocages with tetradecanol to maximize anti-tumor effects on MCF-7/ADR cells. J Colloid Interface Sci 509:47–57CrossRefGoogle Scholar
  18. 18.
    Zhou GY, Xiao H, Li XX, Huang Y, Song W, Song L, Chen MW, Cheng D, Shuai XT (2017) Gold nanocage decorated pH-sensitive micelle for highly effective photothermo-chemotherapy and photoacoustic imaging. Acta Biomater 64:223–236CrossRefGoogle Scholar
  19. 19.
    Du Y, Jiang Q, Beziere N, Song LL, Zhang Q, Peng D, Chi CW, Yang X, Guo HB, Diot G, Ntziachristos V, Ding BQ, Tian J (2016) DNA-nanostructure-gold-nanorod hybrids for enhanced in vivo optoacoustic imaging and photothermal therapy. Adv Mater 28:10000–10007CrossRefGoogle Scholar
  20. 20.
    Yang DP, Liu X, Teng CP, Owh C, Win KY, Lin M, Loh XJ, Wu YL, Li ZB, Ye E (2017) Unexpected formation of gold nanoflowers by a green synthesis method as agents for a safe and effective photothermal therapy. Nanoscale 9:15753–15759CrossRefGoogle Scholar
  21. 21.
    Chen J, Sheng ZH, Li PH, Wu MX, Zhang N, Yu XF, Wang YW, Hu DH, Zheng HR, Wang GP (2017) Indocyanine green-loaded gold nanostars for sensitive SERS imaging and subcellular monitoring of photothermal therapy. Nanoscale 9:11888–11901CrossRefGoogle Scholar
  22. 22.
    Alkilany AM, Murphy CJ (2010) Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? J Nanopart Res 12:2313–2333CrossRefGoogle Scholar
  23. 23.
    Khlebtsov N, Dykman L (2011) Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies. Chem Soc Rev 40:1647–1671CrossRefGoogle Scholar
  24. 24.
    Bozich JS, Lohse SE, Torelli MD, Murphy CJ, Hamers RJ, Klaper RD (2014) Surface chemistry, charge and ligand type impact the toxicity of gold nanoparticles to Daphnia magna. Environ Sci Nano 1:260–270CrossRefGoogle Scholar
  25. 25.
    Guler U, Shalaev VM, Boltasseva A (2015) Nanoparticle plasmonics: going practical with transition metal nitrides. Mater Today 18:227–237CrossRefGoogle Scholar
  26. 26.
    Guler U, Naik GV, Boltasseva A, Shalaev VM, Kildishev AV (2012) Performance analysis of nitride alternative plasmonic materials for localized surface plasmon applications. Appl Phys B 107:285–291CrossRefGoogle Scholar
  27. 27.
    Reinholdt A, Pecenka R, Pinchuk A, Runte S, Stepanov AL, Weirich TE, Kreibig U (2004) Structural, compositional, optical and colorimetric characterization of TiN-nanoparticles. Eur Phys J D 31:69–76CrossRefGoogle Scholar
  28. 28.
    Sun BM, Wu JR, Cui SB, Zhu HH, An W, Fu QG, Shao CW, Yao AH, Chen BD, Shi DL (2017) In situ synthesis of graphene oxide/gold nanorods theranostic hybrids for efficient tumor computed tomography imaging and photothermal therapy. Nano Res 10:37–48CrossRefGoogle Scholar
  29. 29.
    Schneider T, Westermann M, Glei M (2017) In vitro uptake and toxicity studies of metal nanoparticles and metal oxide nanoparticles in human HT29 cells. Arch Toxicol 91:3517–3527CrossRefGoogle Scholar
  30. 30.
    Howell IR, Giroire B, Garcia A, Li S, Aymonier C, Watkins JJ (2018) Fabrication of plasmonic TiN nanostructures by nitridation of nanoimprinted TiO2 nanoparticles. J Mater Chem C 6:1399–1406CrossRefGoogle Scholar
  31. 31.
    Drygaš M, Czosnek C, Paine RT, Janik JF (2006) Two-stage aerosol synthesis of titanium nitride TiN and titanium oxynitride TiOxNy nanopowders of spherical particle morphology. Chem Mater 18:3122–3129CrossRefGoogle Scholar
  32. 32.
    Hoang S, Guo SW, Hahn NT, Bard AJ, Mullins CB (2012) Visible light driven photoelectronchemical water oxidation on nitrogen-modified TiO2 nanowires. Nano Lett 12:26–32CrossRefGoogle Scholar
  33. 33.
    Asahi R, Morikawa T, Ohwaki T, Aoki K, Taga Y (2001) Visible-light photocatalysis in nitrogen-doped titanium oxides. Science 293:269–271CrossRefGoogle Scholar
  34. 34.
    Balogun MS, Yu MH, Li C, Zhai T, Liu Y, Lu XH, Tong YX (2014) Facile synthesis of titanium nitride nanowires on carbon fabric for flexible and high-rate lithium ion batteries. J Mater Chem A 2:10825–10829CrossRefGoogle Scholar
  35. 35.
    Kim BG, Jo CS, Shin J, Mun YD, Lee JW, Choi JW (2017) Ordered mesoporous titanium nitride as a promising carbon-free cathode for aprotic lithium-oxygen batteries. ACS Nano 11:1736–1746CrossRefGoogle Scholar
  36. 36.
    Chithrani BD, Ghazani AA, Chan WCW (2006) Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett 6:662–668CrossRefGoogle Scholar
  37. 37.
    Chithrani BD, Chan WCW (2007) Elucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapes. Nano Lett 7:1542–1550CrossRefGoogle Scholar
  38. 38.
    Lin H, Gao SS, Dai C, Chen Y, Shi JL (2017) A two-dimensional biodegradable niobium carbide (Mxene) for photothermal tumor eradiation in NIR-I and NIR-II biowindows. J Am Chem Soc 139:16235–16247CrossRefGoogle Scholar
  39. 39.
    Liu PY, Miao ZH, Yang HJ, Zhen L, Xu CY (2018) Biocompatible Fe3+-TA coordination complex with high photothermal conversion efficiency for ablation of cancer cells. Colloids Surf B 167:183–190CrossRefGoogle Scholar
  40. 40.
    Liu YL (2018) Multifunctional nanoprobes: from design validation to biomedical applications. Springer Theses. Springer, SingaporeCrossRefGoogle Scholar
  41. 41.
    Li ZB, Huang H, Tang SY, Li Y, Yu XF, Wang HY, Li PH, Sun ZB, Zhang H, Liu CL, Chu K (2016) Small gold nanorods laden macrophages for enhanced tumor coverage in photothermal therapy. Biomaterials 74:144–451CrossRefGoogle Scholar
  42. 42.
    Almada M, Leal-Martínez BH, Hassan N, Kogan MJ, Burboa MG, Topete A, Valdez MA, Juárez J (2017) Photothermal conversion efficiency and cytotoxic effect of gold nanorods stabilized with chitosan, alginate and poly(vinyl alcohol). Mater Sci Eng C 77:583–593CrossRefGoogle Scholar
  43. 43.
    Elshahawy W, Shohieb F, Yehia H, Etman W, Watanbe I, Kramer C (2014) Cytotoxic effect of elements released clinically from gold and CAD–CAM fabricated ceramic crowns. Tanta Dent J 11:189–193CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Key Laboratory of Advanced Civil Engineering Materials, Ministry of EducationTongji UniversityShanghaiChina
  2. 2.School of Materials Science and EngineeringTongji UniversityShanghaiChina
  3. 3.Department of Emergency, Changhai HospitalSecond Military Medical UniversityShanghaiChina
  4. 4.Hebei Provincial Key Laboratory of Inorganic Nonmetallic Materials, College of Materials Science and EngineeringNorth China University of Science and TechnologyTangshanChina

Personalised recommendations