Journal of Materials Science

, Volume 53, Issue 4, pp 2362–2374 | Cite as

In vitro degradation and bioactivity of composite poly-l-lactic (PLLA)/bioactive glass (BG) scaffolds: comparison of 45S5 and 1393BG compositions

  • Gioacchino Conoscenti
  • Francesco Carfì Pavia
  • Francesca Elisa Ciraldo
  • Liliana Liverani
  • Valerio Brucato
  • Vincenzo La CarrubbaEmail author
  • Aldo R. BoccacciniEmail author


The objective of this study was to compare the effect of two bioglass (BG) compositions 45S5 and 1393 in poly-l-lactic composite scaffolds in terms of morphology, mechanical properties, biodegradation, water uptake and bioactivity. The scaffolds were produced via thermally induced phase separation starting from a ternary polymer solution (polymer/solvent/non-solvent). Furthermore, different BG to polymer ratios have been selected (1, 2.5, 5% wt/wt) to evaluate the effect of the amount of filler on the composite structure. Results show that the addition of 1393BG does not affect the scaffold morphology, whereas the 45S5BG at the highest amount tends to appreciably modify the scaffold architecture interacting with the phase separation process. Bioactivity tests confirmed the formation of a hydroxycarbonateapatite-layer in both types of BGs (detected via scanning electron microscopy, X-ray diffractometry and Fourier Transform Infrared Spectroscopy). Overall, the results showed that 1393BG composition affects the experimental preparation protocol to a minimal extent thus allowing a better control of the scaffold’s morphology compared to 45S5BG.



This work has been supported by the Italian Ministry of University and Research (MIUR) (PRIN prot. 20089CWS4C-005).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.Department of Civil Environmental, Aerospace and Materials Engineering (DICAM)University of PalermoPalermoItaly
  2. 2.Department of Materials Science and Engineering, Institute of BiomaterialsUniversity of Erlangen-NurembergErlangenGermany
  3. 3.ATeN Center - CHABUniversity of PalermoPalermoItaly

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