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Journal of Materials Science

, Volume 52, Issue 21, pp 12593–12607 | Cite as

Synthesis and characterization of three novel amphiphilic dextran self-assembled micelles as potential drug delivery system

  • Shubin Li
  • Juanjuan Yi
  • Wei Li
  • Lu WangEmail author
  • Zhenyu Wang
Biomaterials

Abstract

Three types of amphiphilic dextran derivatives were synthesized via the connection of different diamine compounds between the carboxyl group of stearic acid (SA) and aldehyde group of oxidized dextran. These three amphiphilic dextran derivatives self-assemble to form polymer micelles in aqueous medium. The critical micelle concentration depended on the graft ratio of SA, which ranged from 0.0700 to 0.158 mg mL−1. These three amphiphilic dextran micelles can form typical core–shell structures of various sizes. Curcumin (Cur) was used as a model drug, and all amphiphilic micelle dextran derivatives had excellent drug loading capacity and drug encapsulation efficiency. The in vitro drug release from amphiphilic dextran derivatives/Cur micelles could be prolonged by adjusting the type of diamine compounds and composition of Cur content. These results show the superior properties of polymer micelles and suggest that these micelles are promising carriers for drug delivery systems.

Abbreviations

DLS

Dynamic light scattering

WAXRD

Wide-angle X-ray diffraction

TEM

Transmission electron microscopy

SEM

Scanning electron microscopy

SA

Scanning electron microscopy

Cur

Curcumin

HMDA

Hexamethylene diamine

PPD

P-phenylenediamine

ADH

Adipic acid dihydrazide

DMF

N, N-Dimethylformamide

DMSO

Dimethyl sulfoxide

Notes

Acknowledgements

The authors thank Professor Lu Wei-Hong and Professor Ma Ying from the Chemical Engineering Department, Harbin Institute of Technology, for their helpful suggestions and assistance. Funding was provided by National Natural Science Foundation of China (Grant Nos. 21371042, 21271056, 21571044) [Thirteen five national key research and development projects (Grant No. 2016YFC0500307-07), Heilongjiang Province major research projects (Grant No. GA13B202) and the Natural Science Foundation of Heilongjiang Province (Grant Nos. B2015003, ZD2015001, ZD2015001, ZD2015001].

Compliance with ethical standards

Conflict of interest

The authors have declared no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.School of Chemical Engineering and ChemistryHarbin Institute of TechnologyHarbinPeople’s Republic of China

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