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Journal of Materials Science

, Volume 52, Issue 16, pp 9262–9268 | Cite as

Systematic investigation and in vitro biocompatibility studies on implantable magnetic nanocomposites for hyperthermia treatment of osteoarthritic knee joints

  • S. Mohapatra
  • R. Mishra
  • P. Roy
  • K. L. Yadav
  • S. SatapathiEmail author
Biomaterials

Abstract

The inefficacy of the currently used treatment modalities for osteoarthritis has elicited considerable research interest in the exploration of alternative methods. Hyperthermia treatment, generally used in the case of lesions, maybe considered as a viable solution owing to the economic and ergonomic factors involved. In the present study, Cr-doped Fe2O3 embedded in PVDF matrix is proposed as the biocompatible magnetic-dielectric composite to provide thermo-regulated prolonged treatment. A systematic study was carried out to characterize the physical properties of the prepared formulation. Further, cellular uptake studies were done to ensure bioviability. Finite element method studies using COMSOL were used to simulate the hyperthermia treatment of osteoarthritic knee joint. The approach proposed here may be used further to develop a novel class of therapeutic devices for the treatment of osteoarthritis.

Keywords

Fe2O3 Nanoparticles Magnetic Composite Hyperthermia Treatment Nitrate Nonahydrate Prepared Formulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

The authors would like to acknowledge Dr. Shabina Khanam, Chemical Engineering Department, Indian Institute of Technology Roorkee for assisting in the usage of COMSOL. SS like to acknowledge Prof. Max Shtein from University of Michigan, Ann Arbor, USA for useful discussion. For financial support, authors would like to thank Sponsored Research and Industrial Consultancy, IIT Roorkee under Grant SRIC-CONSL-000-414 dt. 09.09.2015. SS like to acknowledge Faculty Initiation Grant from IIT Roorkee.

Compliance with ethical standards

Conflict of interest

All authors would like to declare no conflicts of interest.

Supplementary material

Supplementary material 1 (AVI 64535 kb)

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Metallurgical and Materials Engineering DepartmentIndian Institute of Technology RoorkeeRoorkeeIndia
  2. 2.Department of BiotechnologyIndian Institute of Technology RoorkeeRoorkeeIndia
  3. 3.Department of PhysicsIndian Institute of Technology RoorkeeRoorkeeIndia

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