Engineering the surface functionality of 45S5 bioactive glass-based scaffolds by the heterogeneous nucleation and growth of silver particles
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An emerging topic in the field of biomaterials is the incorporation of silver ions, metallic silver or silver oxides into bioactive glasses to impart novel functionalities. In this work, a new approach of surface functionalization of 45S5 bioactive glass (BG) is introduced. In contrast to more common methods, which are based on the inclusion of silver during the sol–gel synthesis of BG, our method allows the surface functionalization of BG powders and BG scaffolds after their preparation. Hereby, we demonstrate the transferability of a previously reported approach on the wet chemical synthesis of cup-like and dendritic silver patches first from colloidal silica particles to BG particles and further to macroscopic highly porous BG scaffolds which were prepared by the sacrificial foam replica technique. The time-dependent silver releases of BG scaffolds with different silver loadings into simulated body fluid (SBF) were measured. Further studies were addressed to investigate the bioactivity of BG scaffolds before and after the silver coating procedure. It was found the silver deposition on 3D BG scaffolds did not affect the formation of crystalline hydroxyapatite during immersion into simulated body fluid.
KeywordsSimulated Body Fluid Heterogeneous Nucleation Bioactive Glass Silver Particle Silver Coating
The authors are grateful to Fabrizio-Zagros Sadafi for fruitful discussions and for financial support from the Cluster of Excellence “Engineering of Advanced Materials” which is funded by the German Research Foundation (DFG) within the framework of the German Federal and State Excellence Initiative. V. Miguez Pacheco and Aldo R. Boccaccini acknowledge the European Commission funding under the 7th Framework Programme (Marie Curie Initial Training Networks; Grant Number 289958, “Bioceramics for bone repair”).
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Conflict of interest
The authors declare that they have no conflict of interest.
- 5.Kontonasaki E, Zorba T, Papadopoulou L, Pavlidou E, Chatzistavrou X, Paraskevopoulos K, Koidis P (2002) Hydroxy carbonate apatite formation on particulate bioglass in vitro as a function of time. Cryst Res Technol 37:1165–1171. doi: 10.1002/1521-4079(200211)37:11<1165:AID-CRAT1165>3.0.CO;2-R CrossRefGoogle Scholar
- 7.Bretcanu O, Misra SK, Yunos DM, Boccaccini AR, Roy I, Kowalczyk T, Blonski S, Kowalewski TA (2009) Electrospun nanofibrous biodegradable polyester coatings on Bioglass®-based glass-ceramics for tissue engineering. Mater Chem Phys 118:420–426. doi: 10.1016/j.matchemphys.2009.08.011 CrossRefGoogle Scholar
- 16.Miguez Pacheco V, Büttner T, Maçon A, Jones JR, Fey T, de Ligny D, Greil P, Chevalier J, Malchere A, Boccaccini AR (2016) Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair. J Non-Cryst Solids 432:65–72. doi: 10.1016/j.jnoncrysol.2015.03.027 CrossRefGoogle Scholar
- 24.Hoppe A, Meszaros R, Stähli C, Romeis S, Schmidt J, Peukert W, Marelli B, Nazhat SN, Wondraczek L, Lao J, Jallot E, Boccaccini AR (2013) In vitro reactivity of Cu doped 45S5 Bioglass® derived scaffolds for bone tissue engineering. J Mater Chem B 1:5659–5674. doi: 10.1039/c3tb21007c CrossRefGoogle Scholar
- 26.Wu C, Zhou Y, Xu M, Han P, Chen L, Chang J, Xiao Y (2013) Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity, osteostimulation and antibacterial activity. Biomaterials 34:422–433. doi: 10.1016/j.biomaterials.2012.09.066 CrossRefGoogle Scholar
- 27.Bellantone M, Coleman NJ, Hench LL (2000) Bacteriostatic action of a novel four-component bioactive glass. J Biomed Mater Res 51:484–490. doi: 10.1002/1097-4636(20000905)51:3<484:AID-JBM24>3.0.CO;2-4 CrossRefGoogle Scholar
- 43.Macon ALB, Kim TB, Valliant EM, Goetschius K, Brow RK, Day DE, Hoppe A, Boccaccini AR, Kim IY, Ohtsuki C, Kokubo T, Osaka A, Vallet-Regi M, Arcos D, Fraile L, Salinas AJ, Teixeira AV, Vueva Y, Almeida RM, Miola M, Vitale-Brovarone C, Verne E, Holand W, Jones JR (2015) A unified in vitro evaluation for apatite-forming ability of bioactive glasses and their variants. J Mater Sci Mater Med 26:1–10. doi: 10.1007/s10856-015-5403-9 CrossRefGoogle Scholar
- 44.Berzina-Cimdina L, Borodajenko N (2012) Research of calcium phosphates using Fourier transform infrared spectroscopy. In: Theophanides TM (ed) Infrared spectroscopy—materials science, engineering and technology. Rijeka, InTechGoogle Scholar