Bioactive glass coating on gelatin scaffolds at ambient temperature: easy route to make polymer scaffolds become bioactive
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Increasing the bioactivity of polymeric materials used for bone repair is a concern that can be achieved by loading growth factors or using in vitro tissue engineering approach. However, these techniques may have to address regulatory issues as the implants are shifted from the medical device class to the more constraining drug delivery systems. Alternatively, implants can be coated with bioceramics to achieve bioactivity, but existing coating processes can hardly be applied to polymers because they usually involve thermal treatments or sintering. Here we report an efficient way of coating a bioactive glass phase onto a complex polymeric substrate, namely gelatin scaffolds with controlled spherical porosity, at ambient temperature through a dip-coating process. A multiscale analysis of the bioactive glass-coated gelatin scaffolds properties has been carried out. Homogeneous and remarkably uniform layer of SiO2–CaO bioactive glass is obtained. The bioactive glass coating exhibits a very high and fast apatite-forming ability, with full mineralization of the coating being achieved in less than 24 h contact with body fluids. Importantly, the mineralization takes place homogeneously throughout the scaffold while the remarkable uniformity and thickness regularity of the coating are preserved. These features should enhance the in vivo behaviour of polymer scaffolds and make reconsider the interest of non-bioactive polymers for tissue engineering.
KeywordsApatite Simulated Body Fluid Bioactive Glass PIXE Polymer Scaffold
The Conseil Régional d’Auvergne is acknowledged for funding (“New Researcher” Grant). The Centre d’Etudes Nucléaires de Bordeaux-Gradignan and the AIFIRA staff are acknowledged for allowing the PIXE experiments and for technical support.
- 30.Balian G, Bowes JH (1977) The structure and properties of collagen. Academic Press, LondonGoogle Scholar
- 32.Okino H, Manabe T, Tanaka M, Matsuda T (2003) Novel therapeutic strategy for prevention of malignant tumor recurrence after surgery: local delivery and prolonged release of adenovirus immobilized in photocured, tissue-adhesive gelatinous matrix. J Biomed Mater Res Part A 66A(3):643–651CrossRefGoogle Scholar
- 52.Brinker CJ, Scherer GW (1990) Sol-gel science: the physics and chemistry of sol–gel processing. Academic press, New YorkGoogle Scholar
- 63.Keaveny TM, Morgan EF, Yeh OC (2003) Bone biomechanics. In: Kutz M (ed) Standard handbook of biomedical engineering and design. McGraw-Hill Professional, New York, pp 221–243Google Scholar