Journal of Materials Science

, Volume 51, Issue 11, pp 5073–5081

Designing hydrogel nanocomposites using TiO2 as clickable cross-linkers

  • C. García-Astrain
  • M. Miljevic
  • I. Ahmed
  • L. Martin
  • A. Eceiza
  • L. Fruk
  • M. A. Corcuera
  • N. Gabilondo
Original Paper

DOI: 10.1007/s10853-016-9810-1

Cite this article as:
García-Astrain, C., Miljevic, M., Ahmed, I. et al. J Mater Sci (2016) 51: 5073. doi:10.1007/s10853-016-9810-1


Titanium dioxide (TiO2) nanoparticles with clickable functional groups were prepared to allow for the Diels–Alder “click” reaction with a furan-modified pigskin gelatin. Bifunctional dopamine-maleimide linker was employed for TiO2 functionalization with maleimide group. The obtained nanoparticles were characterized using TEM, Zeta potential and FTIR spectroscopy. Functional nanoparticles were subsequently used, together with chondroitin sulphate, as cross-linkers for gelatin hydrogels. Hydrogel controls with bare TiO2 and without nanoparticles were prepared for comparison. The swelling and rheological properties of the nanocomposite hydrogels confirmed the formation of the covalently linked heterogeneous networks. An increase in the storage moduli values was recorded when using maleimide-coated nanoparticles. At the same time, the swelling of the network was significantly reduced indicating the formation of more cross-linked networks. The participation of the surface attached maleimide functional groups through the Diels–Alder cycloaddition was thus confirmed. In addition, hydrogels responded to electrostatic forces as observed by electrostatic force microscopy.

Funding information

Funder NameGrant NumberFunding Note
Basque Country Government
  • Grupos Consolidados (IT-776-13)
Euskal Herriko Unibertsitatea
  • PIFUPV10/034
German Academic Exchange Service

    Copyright information

    © Springer Science+Business Media New York 2016

    Authors and Affiliations

    1. 1.‘Materials + Technologies’ Group, Department of Chemical and Environmental Engineering, Polytechnic SchoolUniversity of the Basque CountryDonostia-San SebastiánSpain
    2. 2.DFG-Centre for Functional Nanostrucutres (CFN)Karlsruhe Institute of TechnologyKarlsruheGermany
    3. 3.Macrobehavior-Mesostructure-Nanotechnology General Research Service (SGIker), Polytechnic SchoolUniversity of the Basque CountryDonostia-San SebastiánSpain

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