Journal of Materials Science

, Volume 51, Issue 8, pp 3824–3835 | Cite as

A model of the mechanical degradation of foam replicated scaffolds

  • M. A. Sulong
  • I. V. Belova
  • A. R. Boccaccini
  • G. E. Murch
  • T. Fiedler
Original Paper
First Online:
Received:
Accepted:

Abstract

Tissue engineering scaffolds are implants that actively support tissue growth whilst providing mechanical support. For optimum functionality, they are designed to slowly dissolve in vivo so that no foreign material remains permanently implanted inside the body. The current study uses a simple degradation model that estimates the change of scaffold geometry due to surface erosion. This model is applied on scaffolds that have been manufactured using the foam replication method. In order to capture their complex geometry, micro-computed tomography scans of samples are obtained. Their change in geometry and degradation of mechanical properties is evaluated using computational analysis. The present investigation found that the mechanical properties such as the quasi-elastic gradient, 0.2 % offset yield stress and the plateau stress are decreased systematically over a 10-week period of immersion time. Deformation analysis on the titania foam scaffold is performed by means of the deformed model obtained from finite element calculations.

Keywords

Simulated Body Fluid Immersion Time Bioactive Glass Elastic Gradient Tissue Engineering Scaffold 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Notes

Acknowledgements

This research was supported by the Australian Research Council through its Discovery Project DP130101377 “Structural design of third generation biomaterials”.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Centre for Mass and Thermal Transport in Engineering Materials, School of EngineeringThe University of NewcastleCallaghanAustralia
  2. 2.Institute of Biomaterials, Department of Materials Science and EngineeringUniversity of Erlangen-NurembergErlangenGermany
  3. 3.Faculty of Mechanical EngineeringUniversiti Teknologi MalaysiaSkudaiMalaysia

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