Journal of Materials Science

, Volume 47, Issue 6, pp 2837–2844 | Cite as

Biomimetic formation of crystalline bone-like apatite layers on spongy materials templated by bile salts aggregates

  • Marcos Fernández-Leyes
  • Valeria Verdinelli
  • Natalia Hassan
  • Juan M. Ruso
  • Olga Pieroni
  • Pablo C. Schulz
  • Paula Messina
Article

Abstract

Since the trabecular bone exhibit sponge-like bicontinuity there is a growing interest in the synthesis of spongy-like sieves for the construction of bio-active implantable materials. Here, we propose a one step sol–gel method for the synthesis of bicontinuous pore silica materials using different bile salts aqueous mixtures as templates. The influences of the type and amount of bile salt on the synthesis processes are investigated and correlated with the final material morphology. As a final point, their structural properties are interrelated with their ability to induce a bone-like apatite layer in contact with simulated body fluid (SBF). We have confirmed that under specific template conditions, the synthesized material has an open bio-active macropore structure that is blanched in a 3D-disordered sponge-like network similar than those existed in trabecular bone.

Notes

Acknowledgements

The authors acknowledge Universidad Nacional del Sur (PGI 24/ZQ07), Concejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina (CONICET, PIP-11220100100072), Xunta de Galicia (Project No. PXI20615PN). MFL and VV have fellowships of CONICET. PM is an adjunct researcher of CONICET.

Supplementary material

10853_2011_6113_MOESM1_ESM.doc (14.7 mb)
Negative staining of template BSs/DDAB aqueous mixed systems, characterization by TEM microphotographs. Material chemical reactivity and HA coatings time evolution analysis by FT-IR. EDX microanalysis of HA coatings (DOC 15002 kb)

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Marcos Fernández-Leyes
    • 1
    • 2
  • Valeria Verdinelli
    • 1
    • 2
  • Natalia Hassan
    • 3
  • Juan M. Ruso
    • 3
  • Olga Pieroni
    • 1
    • 2
  • Pablo C. Schulz
    • 1
    • 2
  • Paula Messina
    • 1
    • 2
  1. 1.Department of ChemistryUniversidad Nacional del SurBahía BlancaArgentina
  2. 2.INQUISUR-CONICETBahía BlancaArgentina
  3. 3.Soft Matter and Molecular Biophysics Group, Department of Applied PhysicsUniversity of Santiago de CompostelaSantiago de CompostelaSpain

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