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Journal of Materials Science

, Volume 46, Issue 18, pp 6087–6095 | Cite as

Ion beam etching titanium for enhanced osteoblast response

  • Nicholas A. Riedel
  • John D. Williams
  • Ketul C. PopatEmail author
Article

Abstract

As the demand for hip and knee replacements continues to grow, researchers look to increase the operational lifetimes of these implants. Many implant failures are attributed to aseptic loosening caused from the repeated loading of these joints. It is believed that by improving the interface between the implant and natural tissue, implant life could be extended. This study evaluates the effects of argon ion etching on Ti6Al4V titanium alloy and the resulting implications this etching has on living cells. Three ion energies (300, 700, and 1100 eV) were used to etch the as-received titanium substrates. Topographical changes were examined by scanning electron microscopy. Etching at 700 and 1100 eV resulted in the formation of a hierarchical structure of micro/nano-texturization of micron-sized depressions with nano-structured ripples. A rat mesenchymal stem cell population was differentiated to an osteoblastic phenotype to test the biocompatibility of the surfaces. It was found that ion etching the titanium results in an improvement of early cellular activity and may enhance osteoblast performance.

Keywords

Etch Rate Titanium Substrate Scanning Electron Microscopy Evaluation FLUOstar Omega Mesenchymal Stem Cell Population 

Notes

Acknowledgements

The authors wish to thank Dr. Timothy Ruckh for his assistance with harvesting the mesenchymal stem cells, as well as Dr. Cody Farnell and Dr. Casey Farnell for their consultation and support of the ion sputtering process. We would also like to thank Abound Solar for the use of their contact angle testing equipment.

References

  1. 1.
    Kim S (2008) Arthritis Rheum 59:481CrossRefGoogle Scholar
  2. 2.
    Fehring TK, Odum S, Griffin WL, Mason JB, Nadaud M (2001) Clin Orthop Relat Res 392:315CrossRefGoogle Scholar
  3. 3.
    Linder L, Carlsson A, Marsal L, Bjursten LM, Branemark PI (1988) J Bone Joint Surg Br 70:550CrossRefGoogle Scholar
  4. 4.
    Branemark PI, Hansson BO, Adell R et al (1977) Scand J Plast Reconstr Surg 16:1Google Scholar
  5. 5.
    Sharkey PF, Hozack WJ, Rothman RH, Shastri S, Jacoby SM (2002) Clin Orthop Relat Res 404:7CrossRefGoogle Scholar
  6. 6.
    Schliephake H, Scharnweber D, Dard M, Sewing A, Aref A, Roessler S (2005) J Biomed Mater Res B 73B:88CrossRefGoogle Scholar
  7. 7.
    Ferris DM, Moodie GD, Dimond PM, Gioranni CW, Ehrlich MG, Valentini RF (1999) Biomaterials 20:2323CrossRefGoogle Scholar
  8. 8.
    Dumbleton J, Manley MT (2004) J Bone Joint Surg Am 86-A:2526CrossRefGoogle Scholar
  9. 9.
    Barrere F, van Blitterswijk CA, de Groot K (2006) Int J Nanomed 1:317Google Scholar
  10. 10.
    Mendonca G, Mendonca DB, Aragao FJ, Cooper LF (2008) Biomaterials 29:3822CrossRefGoogle Scholar
  11. 11.
    Dalby MJ, McCloy D, Robertson M et al (2006) Biomaterials 27:2980CrossRefGoogle Scholar
  12. 12.
    Price RL, Haberstroh KM, Webster TJ (2003) Med Biol Eng Comput 41:372CrossRefGoogle Scholar
  13. 13.
    Rekow D, Van Thompson P, Ricci JL (2006) J Mater Sci 41:5113. doi: https://doi.org/10.1007/s10853-006-0071-2 CrossRefGoogle Scholar
  14. 14.
    Colombo P, Vakifahmetoglu C, Costacurta S (2010) J Mater Sci 45:5425. doi: https://doi.org/10.1007/s10853-010-4708-9 CrossRefGoogle Scholar
  15. 15.
    Hanarp P, Sutherland DS, Gold J, Kasemo B (2003) Colloid Surf A 214:23CrossRefGoogle Scholar
  16. 16.
    Vieu C, Carcenac F, Pepin A et al (2000) Appl Surf Sci 164:111CrossRefGoogle Scholar
  17. 17.
    Morimoto H, Sasaki Y, Saitoh K, Watakabe Y, Kato T (1986) Microelectron Eng 4:163CrossRefGoogle Scholar
  18. 18.
    Gan J, Chen H, Zhou F et al (2010) Colloids Surf B Biointerfaces 76:381CrossRefGoogle Scholar
  19. 19.
    Romanato F, Tormen M, Businaro L et al (2004) Microelectron Eng 73–74:870CrossRefGoogle Scholar
  20. 20.
    Piner RD, Zhu J, Xu F, Hong S, Mirkin CA (1999) Science 283:661CrossRefGoogle Scholar
  21. 21.
    WJ Li, Laurencin CT, Caterson EJ, Tuan RS, Ko FK (2002) J Biomed Mater Res 60:613CrossRefGoogle Scholar
  22. 22.
    Zhou FL, Gong RH, Porat I (2009) J Mater Sci 44:5501. doi: https://doi.org/10.1007/s10853-009-3768-1 CrossRefGoogle Scholar
  23. 23.
    Popat KC, Leoni L, Grimes CA, Desai TA (2007) Biomaterials 28:3188CrossRefGoogle Scholar
  24. 24.
    Malhotra ML (1977) Metallography 10:337CrossRefGoogle Scholar
  25. 25.
    Facsko S, Dekorsy T, Koerdt C et al (1999) Science 285:1551CrossRefGoogle Scholar
  26. 26.
    Ziberi B, Cornejo M, Frost F, Rauschenbach B (2009) J Phys Condens Matter 21:224002CrossRefGoogle Scholar
  27. 27.
    Reiche R, Hauffe W (2000) Appl Surf Sci 165:279CrossRefGoogle Scholar
  28. 28.
    Wei QM, Zhou XL, Joshi B et al (2009) Adv Mater 21:2865CrossRefGoogle Scholar
  29. 29.
    Frost F, Schindler A, Bigl F (2000) Phys Rev Lett 85:4116CrossRefGoogle Scholar
  30. 30.
    Toma A, de Mongeot FB, Buzio R et al (2005) Nucl Instrum Methods B 230:551CrossRefGoogle Scholar
  31. 31.
    Makh SS, Smith R, Walls JM (1982) J Mater Sci 17:1689. doi: https://doi.org/10.1007/BF00540797 CrossRefGoogle Scholar
  32. 32.
    Pelletier J, Anders A (2005) IEEE Trans Plasma Sci 33:1944CrossRefGoogle Scholar
  33. 33.
    Yamamura Y, Tawara H (1996) Atom Data Nucl Data 62:149CrossRefGoogle Scholar
  34. 34.
    Batic BS, Jenko M (2010) J Vac Sci Technol A 28:741CrossRefGoogle Scholar
  35. 35.
    Rusponi S, Costantini G, Boragno C, Valbusa U (1998) Phys Rev Lett 81:4184CrossRefGoogle Scholar
  36. 36.
    Rusponi S, Boragno C, Valbusa U (1997) Phys Rev Lett 78:2795CrossRefGoogle Scholar
  37. 37.
    Bradley RM, Harper JME (1988) J Vac Sci Technol A 6:2390CrossRefGoogle Scholar
  38. 38.
    Anderson HC (2003) Curr Rheumatol Rep 5:222CrossRefGoogle Scholar
  39. 39.
    Boyan BD, Schwartz Z, Swain LD (1992) Bone Miner 17:263CrossRefGoogle Scholar
  40. 40.
    Shin H, Zygourakis K, Farach-Carson MC, Yaszemski MJ, Mikos AG (2004) J Biomed Mater Res A 69:535CrossRefGoogle Scholar
  41. 41.
    Bancroft GN, Sikavitsas VI, van den Dolder J et al (2002) Proc Natl Acad Sci USA 99:12600CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Nicholas A. Riedel
    • 1
  • John D. Williams
    • 1
  • Ketul C. Popat
    • 2
    Email author
  1. 1.Department of Mechanical EngineeringColorado State UniversityFort CollinsUSA
  2. 2.Department of Mechanical Engineering and School of Biomedical EngineeringColorado State UniversityFort CollinsUSA

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