Journal of Materials Science

, Volume 45, Issue 4, pp 1046–1051 | Cite as

Influence of cross-linking density on swelling and estradiol permeation of chitosan membranes

  • Luciano MengattoEmail author
  • Julio A. Luna
  • María I. Cabrera


Chitosan membranes were obtained by a casting/solvent evaporation method and cross-linking with sodium tripolyphosphate. The effect of cross-linking time was studied and the cross-linked membranes were characterized with respect to equilibrium water content, sodium content, IR spectroscopy and permeability to a model drug (Estradiol). Sodium content increased with increasing cross-linking time. Equilibrium water content was higher in the membrane with the lowest cross-linking time. This membrane also showed a higher flux of Estradiol compared with the other which exhibited an increment in equilibrium water content and flux of Estradiol with the increase in cross-linking duration. These dissimilar results could be explained by a significant correlation between the hydrophilicity of the membrane and the hydrophobicity of Estradiol.


Sodium Content Sodium Tripolyphosphate Chitosan Membrane Equilibrium Water Content Potassium Phosphate Monobasic 



The authors thank CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas) and LIF SE (Laboratorio Industrial Farmacéutico SE-Provincia de Santa Fe) for the financial support. The authors also thank Susana Gervasio and Ignacio Rintoul for their substantial contributions and technical assistance.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Luciano Mengatto
    • 1
    Email author
  • Julio A. Luna
    • 1
  • María I. Cabrera
    • 1
  1. 1.Laboratorio de Química Fina, Instituto de Desarrollo Tecnológico para la Industria Química (INTEC)Universidad Nacional del Litoral and Consejo Nacional de Investigaciones Científicas y Técnicas (UNL-CONICET), Centro Científico TecnológicoSanta FeArgentina

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