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Influence of cross-linking density on swelling and estradiol permeation of chitosan membranes

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Abstract

Chitosan membranes were obtained by a casting/solvent evaporation method and cross-linking with sodium tripolyphosphate. The effect of cross-linking time was studied and the cross-linked membranes were characterized with respect to equilibrium water content, sodium content, IR spectroscopy and permeability to a model drug (Estradiol). Sodium content increased with increasing cross-linking time. Equilibrium water content was higher in the membrane with the lowest cross-linking time. This membrane also showed a higher flux of Estradiol compared with the other which exhibited an increment in equilibrium water content and flux of Estradiol with the increase in cross-linking duration. These dissimilar results could be explained by a significant correlation between the hydrophilicity of the membrane and the hydrophobicity of Estradiol.

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Acknowledgements

The authors thank CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas) and LIF SE (Laboratorio Industrial Farmacéutico SE-Provincia de Santa Fe) for the financial support. The authors also thank Susana Gervasio and Ignacio Rintoul for their substantial contributions and technical assistance.

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Authors and Affiliations

  1. Laboratorio de Química Fina, Instituto de Desarrollo Tecnológico para la Industria Química (INTEC), Universidad Nacional del Litoral and Consejo Nacional de Investigaciones Científicas y Técnicas (UNL-CONICET), Centro Científico Tecnológico, Ruta Nacional 168, Paraje El Pozo, 3000, Santa Fe, Argentina

    Luciano Mengatto, Julio A. Luna & María I. Cabrera

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  1. Luciano Mengatto
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  2. Julio A. Luna
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  3. María I. Cabrera
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Correspondence to Luciano Mengatto.

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Mengatto, L., Luna, J.A. & Cabrera, M.I. Influence of cross-linking density on swelling and estradiol permeation of chitosan membranes. J Mater Sci 45, 1046–1051 (2010). https://doi.org/10.1007/s10853-009-4039-x

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  • DOI: https://doi.org/10.1007/s10853-009-4039-x

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