Influence of cross-linking density on swelling and estradiol permeation of chitosan membranes
- 209 Downloads
Chitosan membranes were obtained by a casting/solvent evaporation method and cross-linking with sodium tripolyphosphate. The effect of cross-linking time was studied and the cross-linked membranes were characterized with respect to equilibrium water content, sodium content, IR spectroscopy and permeability to a model drug (Estradiol). Sodium content increased with increasing cross-linking time. Equilibrium water content was higher in the membrane with the lowest cross-linking time. This membrane also showed a higher flux of Estradiol compared with the other which exhibited an increment in equilibrium water content and flux of Estradiol with the increase in cross-linking duration. These dissimilar results could be explained by a significant correlation between the hydrophilicity of the membrane and the hydrophobicity of Estradiol.
KeywordsSodium Content Sodium Tripolyphosphate Chitosan Membrane Equilibrium Water Content Potassium Phosphate Monobasic
The authors thank CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas) and LIF SE (Laboratorio Industrial Farmacéutico SE-Provincia de Santa Fe) for the financial support. The authors also thank Susana Gervasio and Ignacio Rintoul for their substantial contributions and technical assistance.
- 12.McDaniel W (1991) Method 200.3 sample preparation procedure for spectrochemical determination of total recoverable elements in biological tissues. Environmental Services Division, US Environmental Protection Agency, pp 23–29Google Scholar
- 13.Estradiol (2000) US Pharmacopoeia 24/National Formulary 19. US Pharmacopoeial Convention, Rockville, p 676Google Scholar