Low-temperature fabrication of macroporous scaffolds through foaming and hydration of tricalcium silicate paste and their bioactivity
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A low-temperature fabrication method for highly porous bioactive scaffolds was developed. The two-step method involved the foaming of tricalcium silicate cement paste and hydration to form calcium silicate hydrate and calcium hydroxide. Scaffolds with a combination of interconnected macro- and micro-sized pores were fabricated by making use of the decomposition of a hydrogen peroxide (H2O2) solution that acted as a foaming agent and through the hydration of tricalcium silicate cement. It was found possible to control the porosity and pore sizes by adjusting the concentration of the H2O2 solution. The in vitro bioactivity of the highly porous scaffolds was investigated by immersion in simulated body fluid (SBF) for 7 days. Hydroxyapatite (HAp) was formed on the surface of the scaffolds. Their bioactivity could be expected to be as good as that of tricalcium silicate cement, making the material competent for the bone tissue engineering application.
KeywordsFoam Simulated Body Fluid Calcium Hydroxide Bone Tissue Engineering Calcium Silicate Hydrate
The research was supported by the National Basic Science Research Program of China (973 Program) (Grant No.: 2005CB522704), Science and Technology Commission of Shanghai Municipality (Grant No.: 08JC1420800) and the Natural Science Foundation of China (Grant 30730034).
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