Comparison of Ca/P mineralization on the surfaces of poly (ε-caprolactone) composites filled with silane-modified nano-apatite
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This study aims to comparatively investigate the Ca/P mineralization on the surfaces of poly (ε-caprolactone) (PCL) composites with apatite nano-fillers, which were modified with silane coupling agents. Three kinds of silane coupling agents like 3-Methylacryoxypropyltrimethoxy silane (KH560), γ-Methacryloxypropyltrimethoxy silane (KH570), and N-(β-aminoethyl)-γ-aminopropyltrimethoxy silane (KH792) were firstly employed to modify the surfaces of nano-apatite particles, and then silane-modified nano-apatite/PCL composites were prepared by combining solvent dispersion and melting co-blending with hot-pressing methods. The Ca/P mineralization of the modified PCL-Matrix composites was evaluated by soaking in 2-time simulated body fluid (2SBF) at 36.5 °C and pH 7.40 after 21 days. These results showed that the Ca/P mineralization on the surface of the silane-modified composite was same as not modified composite. Apatite obtained on the surface of the modified composite film was of lower crystallinity, 1.62 Ca/P ratio and carbonate ceramic, similar to inorganic composition of bone in biological body, and not notably different from one of not modified PCL composite. This discussion revealed that as-fabricated silane-modified composite could achieve Ca/P mineralization and exhibited the ability of obtaining like-bone apatite on own surface like other bioactive materials.
KeywordsApatite Composite Film Simulated Body Fluid DMAc Silane Coupling Agent
This project was financially supported by Scientific Research Fund of Sichuan Provincial Education Department (08ZA094) and the National Natural Science Foundation of China (No. 30700172), Specialized Research Fund for the Doctoral Program of Higher Education for Young Teacher (20070613019), National Key Project of Scientific and Technical Supporting Programs Fund from MSTC (2006BAI16B01).
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