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Journal of Materials Science

, Volume 44, Issue 7, pp 1858–1867 | Cite as

Preparation, structural characterisation and antibacterial properties of Ga-doped sol–gel phosphate-based glass

  • D. M. PickupEmail author
  • S. P. Valappil
  • R. M. Moss
  • H. L. Twyman
  • P. Guerry
  • M. E. Smith
  • M. Wilson
  • J. C. Knowles
  • R. J. Newport
Article

Abstract

A sol–gel preparation of Ga-doped phosphate-based glass with potential application in antimicrobial devices has been developed. Samples of composition (CaO)0.30(Na2O)0.20−x(Ga2O3)x(P2O5)0.50 where x = 0 and 0.03 were prepared, and the structure and properties of the gallium-doped sample compared with those of the sample containing no gallium. Analysis of the 31P MAS NMR data demonstrated that addition of gallium to the sol–gel reaction increases the connectivity of the phosphate network at the expense of hydroxyl groups. This premise is supported by the results of the elemental analysis, which showed that the gallium-free sample contains significantly more hydrogen and by FTIR spectroscopy, which revealed a higher concentration of –OH groups in that sample. Ga K-edge extended X-ray absorption fine structure and X-ray absorption near-edge structure data revealed that the gallium ions are coordinated by six oxygen atoms. In agreement with the X-ray absorption data, the high-energy XRD results also suggest that the Ga3+ ions are octahedrally coordinated with respect to oxygen. Antimicrobial studies demonstrated that the sample containing Ga3+ ions had significant activity against Staphylococcus aureus compared to the control.

Keywords

Gallium Ga2O3 Phosphate Chain Metaphosphate Composition HEXRD Data 

Notes

Acknowledgements

The authors wish to acknowledge funding from the EPSRC (EP/C000714, EP/C000633 and GR/T21080). We thank STFC for access to the synchrotron and especially Bob Bilsborrow and Mark Roberts of the STFC Daresbury Laboratory for their assistance in the use of stations 16.5 and 9.1, respectively.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • D. M. Pickup
    • 1
    Email author
  • S. P. Valappil
    • 2
  • R. M. Moss
    • 1
  • H. L. Twyman
    • 1
  • P. Guerry
    • 3
  • M. E. Smith
    • 3
  • M. Wilson
    • 4
  • J. C. Knowles
    • 2
  • R. J. Newport
    • 1
  1. 1.School of Physical SciencesUniversity of KentCanterburyUK
  2. 2.Division of Biomaterials and Tissue EngineeringUCL Eastman Dental InstituteLondonUK
  3. 3.Department of PhysicsUniversity of WarwickCoventryUK
  4. 4.Division of Microbial DiseasesUCL Eastman Dental InstituteLondonUK

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