Effect of polyurethane composition and the fabrication process on scaffold properties
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The microdomain structure of polyurethanes (PUR) determines their unique physical properties and makes polyurethanes attractive candidates for various tissue engineering applications. 3D scaffolds based on polyurethanes with different contents of hard segments were fabricated by a salt-leaching/polymer coagulation method. The process parameters were carefully considered, particularly the polymer solution concentration and characteristics of the polyurethane, which are the critical parameters for the control of porosity and pore size distribution. In this study, 3D polyurethane scaffolds were fabricated with interconnected pores and porosity from 64% to 80%. Pore size distribution was evaluated using quantitative image analysis and mercury intrusion porosimetry (MIP). The scaffolds fabricated from polyurethanes with 70 wt.% of hard-domain content were found to have the best compression properties.
KeywordsPolyurethane Pore Size Distribution Hard Segment Mercury Intrusion Porosimetry Pore Throat
This scientific work was financially supported by the Ministry of Science and Higher Education, grant R1301901. The authors wish to thank Professor Andrzej Dworak and Dr. Barbara Trzebicka of Centre of Polymer and Carbon Materials Polish Academy of Sciences for the GPC measurements.
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