Journal of Materials Science

, Volume 43, Issue 21, pp 6881–6889 | Cite as

Techniques of controlling hydrodynamic size of ferrofluid of gelatin-coated magnetic iron oxide nanoparticles

  • Babita Gaihre
  • Myung S. Khil
  • Jung A. Ko
  • Hak Y. Kim


In this study, magnetic iron oxide (IOPs) nanoparticles were coated with gelatin B, and various parameters were investigated to find out effects of those parameters in the overall hydrodynamic size of the colloidal dispersions. Two different types of coating techniques, viz., in situ and separately precipitation/coating technique were investigated. In in situ precipitation/coating technique, precipitation, and coating of the IOPs were done simultaneously, while in separately precipitation/coating technique, the IOPs particles were separately precipitated and purified before surface coating was done. The colloidal dispersion obtained from these two methods showed drastically different viscosities as well as hydrodynamic size. It was found that in situ precipitation/coating technique gave smaller-sized monodispersed particles compare to separately precipitation/coating technique. In addition to the above two techniques, the desolvation/cross-linking technique was also investigated and found to, further, reduce the size of the ferrofluid prepared by the in situ and separately precipitation/coating techniques. The ferrofluids prepared using in situ as well as separately precipitation techniques were highly stable and did not sediment for more than 1 month. However, the desolvation/cross-linking technique gave dispersion with reduced stability. Nevertheless, by adjusting suitable combination of acetone and glyceraldehydes, ferrofluid with better stability could be produced by this technique.


Gelatin Select Area Diffraction Pattern Colloidal Dispersion Hydrodynamic Size Steric Stabilization 



This research was supported by the Regional Research Center Program of the Korean Ministry of Education (KRF-2005-211-D00054) and Korean Research Foundation Grant Funded by the Korean Government (MOEHRD) the center for Healthcare Technology Development, Jeonju 561–756, Republic of Korea.


  1. 1.
    Gupta AK, Gupta M (2005) Biomaterials 26:3995. doi: CrossRefGoogle Scholar
  2. 2.
    Tiraferri A, Chen KL, Sethi R, Elimelech M (2008) J Colloid Interface Sci 324:71. doi: CrossRefGoogle Scholar
  3. 3.
    Saravanan M, Bhaskar K, Maharajan G, Pillai KS (2004) Int J Pharm 283:71. doi: CrossRefGoogle Scholar
  4. 4.
    Young S, Wong M, Tabata Y, Mikos AG (2005) J Control Release 109:256. doi: CrossRefGoogle Scholar
  5. 5.
    Coester C, Nayyar P, Samuel J (2006) Eur J Pharm Biopharm 62:306. doi: CrossRefGoogle Scholar
  6. 6.
    Gaihre B, Parajuli DC, Seo HC, Khil MS, Kim HY (2008) Adsorpt Sci Technol (in press).Google Scholar
  7. 7.
    Gaihre B, Aryal S, Khil MS, Kim HY (2008) J Microencapsul 25:21. doi: CrossRefGoogle Scholar
  8. 8.
    Gaihre B, Khil MS, Kang HK, Kim HY (2008) J Mater Sci: Mater Med (in press)Google Scholar
  9. 9.
    Berry CC (2004) J Mater Chem 15:543. doi: CrossRefGoogle Scholar
  10. 10.
    Zhang JL, Srivastava RS, Misra RDK (2007) Langmuir 23:6342. doi: CrossRefGoogle Scholar
  11. 11.
    Zhang Y, Kohler N, Zhang M (2002) Biomaterials 23:1553. doi: CrossRefGoogle Scholar
  12. 12.
    Harris LA, Goff JD, Carmichael AY, Riffle JS, Harburn JJ, Pierre TGS et al (2003) Chem Mater 15:1367. doi: CrossRefGoogle Scholar
  13. 13.
    Bourlinos AB, Bakandritsos A, Georgakilas V, Petridis D (2000) Chem Mater 14:3226. doi: CrossRefGoogle Scholar
  14. 14.
    Loeb J (1924) Proteins and the theory of colloidal behavior. McGraw-Hill, New YorkGoogle Scholar
  15. 15.
    Kunitz M (1927) J Gen Physiol 10:811. doi: CrossRefGoogle Scholar
  16. 16.
    Northrop JH (1928) J Gen Physiol 12:529. doi: CrossRefGoogle Scholar
  17. 17.
    Kamyshny A, Toledano O, Magdassi S (1999) Colloids Surf B Biointerfaces 13:187. doi: CrossRefGoogle Scholar
  18. 18.
    Bele M, Gaberscek M, Dominko R, Drofenik J, Zupan K, Komac P et al (2002) Carbon 40:1117. doi: CrossRefGoogle Scholar
  19. 19.
    Hone JHE, Howe AM, Whitesides TH (2000) Colloids Surf A Physicochem Eng Asp 161:283. doi: CrossRefGoogle Scholar
  20. 20.
    Leo E, Vandelli MA, Cameroni R, Forni F (1997) Int J Pharm 155:75. doi: CrossRefGoogle Scholar
  21. 21.
    Shirad A, Huang Y, Chen H, McQuarrie S, Abrams D, Rao W et al (2006) J Pharm Pharm Sci 9:124Google Scholar
  22. 22.
    Alma JK, Gerard HME, Jeroen K, Sebastian AJZ, Jacob D, Jan F (1999) J Biomater Sci Polym Ed 11:225Google Scholar
  23. 23.
    Cornell RM, Schwertmann U (2000) The iron oxides. Wiley, Weinheim, GermanyGoogle Scholar
  24. 24.
    Illes E, Tombacz E (2006) J Colloid Interface Sci 295:115. doi: CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Babita Gaihre
    • 1
  • Myung S. Khil
    • 2
    • 3
  • Jung A. Ko
    • 1
  • Hak Y. Kim
    • 2
    • 3
  1. 1.Department of Bionanosystem EngineeringChonbuk National UniversityChonjuRepublic of Korea
  2. 2.Center for Healthcare Technology DevelopmentChonbuk National UniversityChonjuRepublic of Korea
  3. 3.Department of Textile EngineeringChonbuk National UniversityChonjuRepublic of Korea

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