Journal of Materials Science

, Volume 43, Issue 6, pp 1939–1947 | Cite as

Supercritical CO2 processing of polymers for the production of materials with applications in tissue engineering and drug delivery

  • Ana M. López-Periago
  • Arlette Vega
  • Pascale Subra
  • Anna Argemí
  • Javier Saurina
  • Carlos A. García-González
  • Concepcion Domingo


Supercritical carbon dioxide (SCCO2) was used for the preparation of foamed sponges and intermingled fibers of biopolymers with potential applications in tissue engineering and drug delivery. The work was focused on the processing of both biodegradable polylactic acid (l-PLA) and non-biodegradable polymethylmethacrylate (PMMA) homopolymers. Monolithic porous sponges of amorphous PMMA were prepared using SCCO2 as a porogen agent by simple swelling and foaming. Under similar experimental conditions, l-PLA was crystallized. The study also addresses the impregnation of biopolymers with an active agent dispersed in SCCO2. The drug used for impregnation was triflusal, a platelet antiaggregant inhibitor for thrombogenic cardiovascular diseases. Foaming often leads to a closed pore structure after depressurization which is disadvantageous for 3D scaffolds as it does not fulfill the requirement of interconnectivity necessary for cell migration. To overcome these drawbacks, fibers forming macroporous structures were prepared using a semicontinuous antisolvent (SAS) technique.


Foam PMMA Supercritical Carbon Dioxide Semicrystalline Polymer Triflusal 



The financial support of EU Project STRP SurfaceT NMP2-CT-2005-013524 and the Spanish MEC (projects MAT2005-25567-E, MAT-2006-28189-E and MAT2005-25503-E) are greatly acknowledged. A. M. Lopez-Periago and C. A. García-González give acknowledgment to CSIC for its funding support through I3P fellowships.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Ana M. López-Periago
    • 1
  • Arlette Vega
    • 2
  • Pascale Subra
    • 2
  • Anna Argemí
    • 3
  • Javier Saurina
    • 3
  • Carlos A. García-González
    • 1
  • Concepcion Domingo
    • 1
  1. 1.Instituto de Ciencia de Materiales de Barcelona, CSICBellaterraSpain
  2. 2.Laboratoire d’Ingénierie des Matériaux et des Hautes Pressions, C.N.R.S.Institut Galilée, Université Paris 13VilletaneuseFrance
  3. 3.Department of Analytical ChemistryUniversity of BarcelonaBarcelonaSpain

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