Porous methacrylate tissue engineering scaffolds: using carbon dioxide to control porosity and interconnectivity

  • John J. A. Barry
  • Marta M. C. G. Silva
  • Sarah H. Cartmell
  • Robert E. Guldberg
  • Colin A. Scotchford
  • Steven M. Howdle
Article

Abstract

Porous scaffold structures are used in tissue engineering to provide structural guidance for regenerating tissues. The use of carbon dioxide (CO2) to create such scaffolds has received some attention in the past but many researchers believe that although CO2 processing of polymers can lead to porous scaffolds there is limited interconnectivity between the pores. In this study, highly porous (greater than 85%) and well interconnected scaffolds were obtained in which the size, distribution and number of pores could be controlled. This control was achieved by altering the rate of venting from polymer discs saturated with CO2 under modest temperature and pressure. The polymer used is a blend of poly (ethyl methacrylate) and tetrahydrofurfuryl methacrylate (PEMA/THFMA). This polymer system has shown promise for potential applications in cartilage repair.

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Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  • John J. A. Barry
    • 1
  • Marta M. C. G. Silva
    • 1
  • Sarah H. Cartmell
    • 2
  • Robert E. Guldberg
    • 2
  • Colin A. Scotchford
    • 3
    • 4
  • Steven M. Howdle
    • 1
  1. 1.School of ChemistryUniversity of NottinghamUniversity ParkUK
  2. 2.Orthopaedic Bioengineering Laboratory, Woodruff School of Mechanical EngineeringGeorgia Institute of TechnologyAtlantaUSA
  3. 3.School of Biomedical SciencesUniversity of Nottingham Medical School, Queen’s Medical CentreNottinghamUK
  4. 4.Bioengineering Section, School of Mechanical, Materials, Manufacturing Engineering and ManagementUniversity of NottinghamNottinghamUK

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