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Journal of Materials Science

, Volume 42, Issue 15, pp 6067–6073 | Cite as

Long-term antimicrobial polyamide 6/silver-nanocomposites

  • Cornelia DammEmail author
  • Helmut Münstedt
  • Alfons Rösch
Article

Abstract

Elemental silver nanoparticles were generated in polyamide 6 (PA6) by the thermal reduction of silver ions during the melt processing of a PA6/silver acetate mixture. The silver ion release from PA6 filled with 2 wt% nanosilver obeys a zero-order rate law for at least 100 days. During this time about 17 μg silver per day, per litre immersion liquid and per cm2 sample surface are released. The PA6/Ag-nanocomposite was shown to be active against Escherichia coli whereas the pure PA6 did not show any antimicrobial efficacy. Immersion of a nanocomposite containing 2 wt% silver in water for 100 days does not reduce its antimicrobial efficacy against Escherichia coli. Thus PA6 filled with 2 wt% nanosilver is an effective antimicrobial material for long-term applications.

Keywords

Silver Nanoparticles Immersion Time Silver Particle Antimicrobial Efficacy Immersion Liquid 

Notes

Acknowledgement

The authors are grateful for financial support from the German Research Foundation (DFG). Many thanks to Dr. E. Ingolic and Dr. H. Schröttner from the Research Center of Electron Microscopy in Graz (Austria) for performing TEM investigations.

References

  1. 1.
    Malassney P, Goeau-Brissonniere O, Coggia M, Pechere JC (1996) J Antimicrob Chemoth 37:121CrossRefGoogle Scholar
  2. 2.
    Kalyon BD, Olgun U (2001) J Infection Control 29:124CrossRefGoogle Scholar
  3. 3.
    Stickler DJ (2000) Curr Opin Infect Dis 13:389CrossRefGoogle Scholar
  4. 4.
    Golubovich VN, Rabotnova IL (1974) Microbiology 43:948Google Scholar
  5. 5.
    Russel AD, Hugo WB (1994) Prog Med Chem 31:351CrossRefGoogle Scholar
  6. 6.
    Feng QL, Wu J, Chen GQ, Cui FZ, Kim TN, Kim JOA (2000) J Biomed Mater Res 52:662CrossRefGoogle Scholar
  7. 7.
    (a) Schierholz JM, Lucas LJ, Rump AFE, Pulverer G (1998) J Hosp Infect 40:257; (b) Schierholz JM, Beuth J, Rump AFE, König DP, Pulverer G (1999) Mat-wiss Werkstofftech 30:869; (c) Schierholz, JM, Seyfert UT, Rump AFE, Beuth J, Pulverer G (1999) Infusion Th Trans Med 26:278Google Scholar
  8. 8.
    Darouiche RO (1999) Clin Infect Dis 29:1371CrossRefGoogle Scholar
  9. 9.
    Guggenbichler J-P (guest editor) (1998) Infection 26(Suppl. 1) (german edition):1Google Scholar
  10. 10.
    Guggenbichler J-P (2003) Mat-wiss Werktofftech 34(12):1145CrossRefGoogle Scholar
  11. 11.
    Dunn K (2004) Burns 30(Suppl 1):1CrossRefGoogle Scholar
  12. 12.
    Holder IA, Durkee P, Supp AP, Boyce ST (2003) Burns 29:445CrossRefGoogle Scholar
  13. 13.
    Ovington LG (2004) Ostomy/Wound Management 50(9A Suppl):1Google Scholar
  14. 14.
    Klueh U, Wagner V, Kelly S, Johnson A, Bryers JD (2000) J Biomed Mater Res (Appl Biomater) 53:621CrossRefGoogle Scholar
  15. 15.
    Tweden KS, Cameron JD, Razzouk AJ, Bianco RW, Holmberg WR, Bricault RJ, Barry JE, Tobin E (1997) Am Soc Art Int Org J 43:M475CrossRefGoogle Scholar
  16. 16.
    Alt V, Bechert T, Steinrücke P, Wagener M, Seidel P, Dingeldein E, Domann E, Schnettler R (2004) Biomaterials 25:4383CrossRefGoogle Scholar
  17. 17.
    Kumar R, Howdle S, Münstedt H (2005) J Biomed Mater Res Part B: Appl Biomater 75B:311CrossRefGoogle Scholar
  18. 18.
    Hoskins JS, Karanfil T, Serkiz SM (2002) Environ Sci Technol 36:784CrossRefGoogle Scholar
  19. 19.
    Damm C (2005) Polym & Polym Comp 13(7):649Google Scholar
  20. 20.
    Kumar R, Münstedt H (2005) Biomaterials 26(14):2081CrossRefGoogle Scholar
  21. 21.
    Aymonier C, Schlotterbeck U, Antonietti L, Zacharias P, Thomann R, Tiller JC, Mecking S (2002) Chem Comm 24:3018CrossRefGoogle Scholar
  22. 22.
    Joyce-Wöhrmann RM, Hentschel T, Münstedt H (2000) Adv Eng Mat 2(6):380CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Cornelia Damm
    • 1
    Email author
  • Helmut Münstedt
    • 1
  • Alfons Rösch
    • 2
  1. 1.Friedrich-Alexander-University Erlangen-Nuremberg, Institute of Polymer MaterialsErlangenGermany
  2. 2.Friedrich-Alexander-University Erlangen-Nuremberg, Institute of MicrobiologyErlangenGermany

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