Influence of two changes in the composition of an acrylic bone cement on some of its properties: the case of Surgical Simplex® P
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Self-curing acrylic bone cements are widely used in orthopaedic surgery for the fixation of joint prostheses  and in vertebroplasty and kyphoplasty  for the stabilisation and/or augmentation of fractured vertebrae. The cement’s curing process is the result of a free-radical polymerisation of a mixture of poly (methy1 methacrylate) [PMMA]-containing powder and a liquid monomer that has methyl methacrylate (MMA) in it, that is initiated by the decomposition of benzoyl peroxide (BPO) in the powder, activated/co-initiated by a tertiary amine (usually, N,N-dimethyl-4-toluidine [DMPT)]) in the monomer, and stabilised by, usually, hydroquinone in the monomer. There are three very important aspects of this polymerisation process. First, only a small amount (typically, 0.1%) of the DMPT is consumed during the polymerisation process, the balance remaining in the cement . Thus, for example, in a cemented arthroplasty, there is the potential that, over the in situ life of the implant,...
KeywordsPMMA Tertiary Amine Benzoyl Peroxide Methemoglobinemia Cement Mantle
The authors thank Stryker Howmedica Osteonics (Limerick, Ireland) for donating generous amounts of all the materials that were used to make the experimental formulations used in the study.
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