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Formation & specification of host–guest inclusion complexes of an anti-malarial drug inside into cyclic oligosaccharides for enhancing bioavailability

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Abstract

The purpose of this novel research is to explore the formation of inclusion complexes of a drug, namely, chloroquine diphosphate with cyclic oligosaccharides. The solubility, versatility and bioavailability of the drug are enhanced and some of its side effects are reduced after encapsulation. Various sophisticated approaches have been employed to synthesize and characterize the inclusion phenomenon, which confirm the 1:1 stoichiometry of the complexes. The association constant is found higher in case of β-cyclodextrin which was explicated based on their molecular structure. The work explores the enhancement of overall bioavailability of this essential biologically active molecule.

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Acknowledgements

Authors convey their thanks to the SAP, Department of Chemistry, UNB under UGC, New Delhi for financial support and necessary instruments to complete the research work. Prof. Roy was also very thankful to UGC, New Delhi, Government of India, for being honored grant under basic scientific research.

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Correspondence to Mahendra Nath Roy.

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Roy, A., Saha, S., Roy, D. et al. Formation & specification of host–guest inclusion complexes of an anti-malarial drug inside into cyclic oligosaccharides for enhancing bioavailability. J Incl Phenom Macrocycl Chem (2020). https://doi.org/10.1007/s10847-020-00984-1

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Keywords

  • Cyclodextrin
  • Chloroquine diphosphate
  • Inclusion complex
  • Thermodynamics
  • Bioavailability