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Biomimetic approach towards the preparation of hydroxyapatite and hydroxyapatite/chitosan/β-cyclodextrin nanoparticles: application to controlled drug release

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Abstract

Hydroxyapatite (HAp) and hydroxyapatite/chitosan/β-cyclodextrin (HAp/CS/β-CD) nanoparticles were successfully prepared in the modified simulated body fluid (SBF) solution at the physiological conditions (pH 7.4, temperature = 37 °C). CS/β-CD nanoparticles acted as templates for the synthesis of HAp/CS/β-CD nanoparticles to improve the nanoarchitecture of HAp and its crystallinity.The nanoparticles were characterized by FT-IR spectroscopy, scanning electron microscopy (SEM), and X-ray diffraction (XRD). Kneading and coprecipitation methods were applied to prepare the inclusion complex involving β-CD and p-THPP (5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin), a photosensitizer for anti-cancer drugs. The 1:1 stoichiometric ratio of the formed inclusion complex was characterized by a formation constant of 7.216 × 102 mol−1 dm3 and analyzed by 1H NMR, FTIR, and UV–Vis. The p-THPP delivery release in vitro was in this order: HAp/CS/β-CD < CS/β-CD < < HAp/β-CD < β-CD, hinting at a better controlled release by HAp/CS/β-CD nanoparticles.

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Author notes

  1. Professor Kheireddine Bal was deceased on March 27th, 2011; this posthumously realized work was one of his research projects.

Authors and Affiliations

  1. Laboratoire de Chimie-Physique Moléculaire et Macromoléculaire, Département de Génie des Procédés, Faculté de Technologie, Université Saâd Dahlab de Blida 1, Route de Soumâa, B. P. 270, 09000, Blida, Algeria

    Fatima Mzyène & Saâd Moulay

  2. Département de Chimie, Faculté des Sciences, Université Saâd Dahlab de Blida 1, Route de Soumâa, B. P. 270, 09000, Blida, Algeria

    Fatima Mzyène & Kheireddine Bal

  3. Laboratory of Computational Chemistry and Nanostructures, Department of Material Sciences, Faculty of Mathematical, Informatics and Material Sciences, University of 08 Mai 1945, Guelma, Algeria

    Fatiha Madi

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  1. Fatima Mzyène
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Mzyène, F., Moulay, S., Bal, K. et al. Biomimetic approach towards the preparation of hydroxyapatite and hydroxyapatite/chitosan/β-cyclodextrin nanoparticles: application to controlled drug release. J Incl Phenom Macrocycl Chem 92, 381–394 (2018). https://doi.org/10.1007/s10847-018-0842-9

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